复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (10): 1139-1143.

复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响

邓阿黎¹, 周忠明¹, 向楠¹, 姜惠中¹, 张亚兵², 金晶¹, 余念¹, 陈露¹

¹湖北中医学院附属医院妇产科, 武汉 430061, 湖北;
²武汉大学中南医院中医科, 武汉 430070, 湖北

收稿日期:2008-08-07 修回日期:2008-10-05 出版日期:2008-10-26 发布日期:2020-10-19
作者简介:邓阿黎, 医学博士, 主治医师, 主要从事中西医结合妇产科疾病的临床、科研及教学工作。Tel:13971220416 E-mail:dengali027@yahooo.com.cn
基金资助:
武汉市科技厅科技攻关项目(20055102032-4)

Influence of traditional Chinese medicine on PCOS rat model serum sex hormone T, FSH, LH, and Leptin

DENG A-li¹,ZHOU Zhong-ming¹, XIANG Nan¹, JIANG Hui-zhong¹, ZHANG Ya-bing², JING Jing¹, YU Nian¹, CHEN Lu¹

¹Department of Gynaecology and Obstetrics Affiliated Hospital, Hubei College of Traditional Chinese Medicine, Wu-han430061, Hubei, China;
²Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan University,Wuhan430070, Hubei, China

Received:2008-08-07 Revised:2008-10-05 Online:2008-10-26 Published:2020-10-19

摘要/Abstract

摘要： 目的: 观察多囊卵巢综合征(PCOS) 模型大鼠血清性激素 T 、FSH 、LH 及瘦素(Leptin) 水平的变化, 探讨复方中药对 PCOS 模型大鼠生殖内分泌系统的影响。方法: 本实验采用 Poresky 法进行造模, 并分别以中药、西药(罗格列酮)、中西药联合用药治疗, 观察治疗后大鼠体重、血清性激素及Leptin 水平的变化, 并进行 Leptin 水平与 FSH、LH 、LH/FSH 、T 、WEIGHT 的相关分析。结果: 复方中药能降低血清 T 、LH 、Leptin 水平及 LH/FSH 比值, 且血清 Leptin 水平与 LH 、T 呈正相关。结论:复方中药能改善 PCOS 模型大鼠的生殖内分泌功能, 降低血清 Leptin 水平。

关键词: 中药, 多囊卵巢综合征, T, FSH, LH, 瘦素

Abstract: AIM: To observe the changes of serum sex hormone T, FSH, LH and Leptin, and explore the influence of traditonal Chinese medicine complex on the reproduction endocrine system in PCOS rat model. METHODS: PCOS rat model was established by Poresky method, the changes of the rats weight, serum sex hormone T,FSH, LH and Leptin were observed af-ter the treatment with traditional Chinese medicine, western medicine (rosiglitazone) , united medication, respectively, and the correlations of serum Leptin levels with FSH, LH, LH/FSH, T, Weight were analyzed. RESULTS: The traditional Chinese medicine group could decrease serum sex hormone T, LH, Leptin level and the LH/FSH, Leptin level and LH, T were positive correlated in model rats. CONCLUSION: The traditional Chinese medicine can improve reproduction en-docrine system functoins and decrease serum Leptin levels on PCOS rat model.

Key words: traditional Chinese medicine, PCOS, T, FSH, LH, Leptins

中图分类号:

R965.2

邓阿黎, 周忠明, 向楠, 姜惠中, 张亚兵, 金晶, 余念, 陈露. 复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响[J]. 中国临床药理学与治疗学, 2008, 13(10): 1139-1143.

DENG A-li,ZHOU Zhong-ming, XIANG Nan, JIANG Hui-zhong, ZHANG Ya-bing, JING Jing, YU Nian, CHEN Lu. Influence of traditional Chinese medicine on PCOS rat model serum sex hormone T, FSH, LH, and Leptin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(10): 1139-1143.

参考文献

[1] Dunaif A.Hyperandrogenic anovulation(pcos) :a unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus[J] .Am J Med, 1995, 98(Suppl) :33-39.
[2] 陈晓平, 杨文英, 卜石, 等.罗格列酮和二甲双胍对高脂饲养造成的胰岛素抵抗的影响[J] .中华内科杂志, 2004, 43(4) :280-283.
[3] 张以文. 多囊卵巢综合征的现代概念[J] .中华妇产科杂志, 2004, 39(9) :577-578.
[4] 蔡丽慧, 张秀兰, 刘云莲.中西医结合治疗多囊卵巢综合征的临床研究[J] .中医函授通讯, 1997, 16(3) :38.
[5] 俞瑾, 孙月丽, 邵公权, 等.补肾化痰治疗多囊卵巢综合征中对下丘脑-垂体-卵巢功能的调节[J] .中西医结合杂志, 1986, (4) :218.
[6] 罗元恺. 实用中医妇科学[M] .上海:上海科学技术出版社, 1996:290.
[7] 朱文新.妇产科情报资料. 1989-1990, (3) :33.
[8] 中国中西医结合研究会第一次全国活血化瘀学术会议:血瘀证诊断试行标准[S] .中西医结合杂志,1983, 3(3) :封二.
[9] 周璐, 章巧萍, 徐孝平, 等.徐小玉生精汤对雄激素致无排卵模型大鼠卵巢功能及形态学的影响[J] .浙江中医药大学学报, 2006, 30(6) :621-622.
[10] 姜荣华. 罗格列酮和二甲双胍对多囊卵巢综合征胰岛素抵抗的治疗研究[J] .武汉大学硕士学位论文,2005.
[11] Zhang Y, Proenca R, Maffei M, et al.Positional cloning of the mouse obese its human homologue[J] .Nature, 1994,372(6505) :425-432.
[12] Brzechffa PR, Jakimiuk AJ, Agarwal SK, et al.Serum im-munoreactive leptin concentrations in women with polycys-tic ovary syndrome[J] .J Clin Endocrinol Metab, l996, 81(11) :4166-4169.
[13] Micic D, Macut D, Popovic V, et al.Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome[J] .Gynecol Endocrinol, 1997,11(5) :315-320.
[14] ElOrabi H, Ghalia AA, Khalifa A, et al. Serum leptin as an additional possible pathogenic factor in polycystic ovary syndrome[J] .Clin Biochem, 1999, 32(1) :71-75.
[15] Knowalska I, Kinalski M, Straczkowski M, et al.Insulin,leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with poly-cystic ovary syndrome[J] .Eur J Endocrinol, 2001, 144(5) :509-515.
[16] Takeuchi T, Tsutsumi O.Basal leptin concentrations in women with normal and dysfunctional ovarian conditions[J] .Int J Gynaecol obstet, 2000, 69(2) :127-133.