核转录因子κB 活化途径干预对肝细胞癌变的影响

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (2): 228-233.

核转录因子κB 活化途径干预对肝细胞癌变的影响

于洪波, 姚登福

南通大学附属医院临床分子生物学中心, 南通 226001, 江苏

收稿日期:2007-08-09 修回日期:2007-10-31 出版日期:2008-02-26 发布日期:2020-10-14
通讯作者: 姚登福, 男, 博士, 教授, 博硕士生导师, 研究方向:肿瘤早期诊断及机制研究。Tel:0513-85052297 　E-mail:yaodf@ahnmc.com
作者简介:于洪波, 男, 硕士研究生, 研究方向:肝癌早期诊断及其分子机制研究。Tel:13813721342 E-mail:bhy@163.com
基金资助:
江苏省“ 六大人才高峰” 资助项目(2006-B-063)

Intervention of NF-κB activation pathway and its effects on malignant transformation of hepatocytes

YU Hong-bo, YAO Deng-fu

Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China

Received:2007-08-09 Revised:2007-10-31 Online:2008-02-26 Published:2020-10-14

摘要/Abstract

摘要： 肝癌发生是一多中心、多病因、多阶段的发展过程。本文对NF-κB 活化途径干预与肝细胞癌变关系的研究进展进行简单的综述。NF-κB 的过度表达参与了肝癌的发生、发展。NF-κB 表达的进行性增加, 可反映肝细胞的早期癌变。而抑制NF-κB 的活性可干预肝细胞恶性转化过程, 可能成为肝癌治疗的新方向。

关键词: NF-κB, 肝癌, 信号通路, 活化途径, 干预

Abstract: The formation of hepatocellular carcinoma (HCC) is a multi-center, multi-etiology and multistage pathological progress with the chronic persistent infection of hepatitis viruses (HBV and HCV). The mutations of multigenes, oncogenes or anti-oncogenes at different stages are the molecular basics of hepatocarcinogenesis. NF-κB participates in initiation and progress of HCC, and the increasing of its expresssion may indicate the early cancerization of hepatocytes. Since NF-κB activation plays an important role in HCC development, the malignant transformation of hepatocytes may be interfered by inhibition of its activation. The approaches such as IKK-B gene knockout or expression of IκBαsuper repressor have been used to intervene the malignant transformation of hepatocytes to explore the molecular mechanisms and application values of HCC therapy.

Key words: NF-κB, hepatoma, signal pathway, activation pathway, intervention

中图分类号:

R735.7

于洪波, 姚登福. 核转录因子κB 活化途径干预对肝细胞癌变的影响[J]. 中国临床药理学与治疗学, 2008, 13(2): 228-233.

YU Hong-bo, YAO Deng-fu. Intervention of NF-κB activation pathway and its effects on malignant transformation of hepatocytes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 228-233.

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