G蛋白β3亚基C825T多态性与原发性高血压

摘要/Abstract

摘要： G 蛋白在信号转导过程中起着重要的作用, 介导许多血管活性及增殖有关的细胞内效应,所以该位点的多态性与心血管疾病特别是原发性高血压之间的关系得到普遍关注。GNB3 C825T多态性在不同种族间的分布不同, 本文主要关注该多态在不同种族中与原发性高血压及它与不同种类降压药物疗效之间的关系。

关键词: G 蛋白, GNB3 C825T, 多态性, 原发性高血压, 疗效

Abstract: G protein plays an important role in the process of signal transduction.It mediates many intracellular effects of blood vessel competent and proliferation.So pharmacologists are very interested in the relation of its polymorphisms and cardiovascular diseases particular essential hypertension.GNB3 C825T polymorphism distributes differently in various populations. We focus on the relation of GNB3 C825T polymorphism with essential hypertension in different populations, and therapeutic effects on hypotensive drugs.

Key words: Gprotein, GNB3 C825T, polymorphism, essential hypertension, therapeutic effects

中图分类号:

R968
R544.1

黄海英, 周宏灏. G蛋白β3亚基C825T多态性与原发性高血压[J]. 中国临床药理学与治疗学, 2008, 13(3): 355-360.

HUANG Hai-ying, ZHOU Hong-hao. GNB3 C825T and essential hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(3): 355-360.

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