关键词: 瓦松提取物, 胃溃疡, 大鼠, 小鼠

Abstract: AIM: To investigate the antiulcer effects of fimbriate orostachys herb extractive on experimental gastroheloma animals.METHODS: Five kinds of animal models with experimental gastric ulcer were established and gastric mucosal injuries were induced by applying indomethac or imposing stress in mice, applying ethanol or acetic acid or pyloric ligation in rats, respectively. The rats were divided into experimental groups treated with fimbriate orostachys herb extractive 400，200，100 mg/kg, positive ontol group,and model control group. The mice were divided into experimental goups treated with fimbriate orostachys herb extractive 800, 400, 200 mg/kg, positive control group, and model group. The gastric ulcer index, gastric juice free acid output, total acid output were measured in animals. RESULTS: Administration with fimbriate orostachys herb extractive 400 and 800 mg/kgwere able to reduce the ulcer index of rats with stressu lceration(P<0.05)，and 200一800mg/kg doses of fimbriate orostachys herb extractive were able to reduce the ulcer index of mice with gastohelcoma induced by indomethac (P<0.05 or P< 0.01)and rats with gastrohelcoma induced by ethanol (P< 0.05),mean while, the gastric ulcer healing in gastrohelcoma rats accused by acetic acid was promoted obviously, but there was no significant influence on gastric secretion and pepsase. CONCLUSION: Fimbriate orostachys herb extractive has evident preventive and therapeutical effects on experimental gastrohe lcoma animals.

Key words: fimbriate orostachys herb extractive, gastrohelcoma, rat, mouse