关键词: 姜黄素3, 四氯化碳, 急性肝损伤模型, 脂质体, 作用机制

Abstract: AIM: To evaluate the therapeutic effects of bisdemethoxycurcumin liposome in mice with CCL induced acute liver injury model and its mechanism. METHODS: 40 ICR mice were randomly divided into 4 groups: ontrol goup, model group, bisdemethoxycurcumin injection group and demethoxycurcumin liposome gloup (n= 10). The liver injury model was made by injecting CCl4 in mouse's abdomen. The activities of ALT, AST in serum, the contents of MDA in liver and the pathological changes of hepatic tissue were investigated. RESULTS: Compared with those in control group, the serum ALT, AST activities and liver MDA contents of model group were highly increased,but those in bisdemethoxycurcumin injection group and bisdemethoxycurcumin liposome group were reduced significantly. The liver lobules were ameliorated obviously too, especially in bisdemethoxycurcumin liposome group. The phamacodynamic action of liposome was better than that of the in jection. CONCLUSION: Bisdemethoxycurcumin liposome has significantly protective effects on CCl-induced acute chemical liver injury by reducing peroxidation of lipid in endotheliocyte of the liver.

Key words: bisdemethoxycurcumin, CCl₄, acute liver injuy model, liposome, mechanism of action