视黄醇结合蛋白4遗传多态性与2型糖尿病的关系

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (4): 452-456.

视黄醇结合蛋白4遗传多态性与2型糖尿病的关系

周芳, 周宏灏, 刘昭前

中南大学临床药理研究所,遗传药理学湖南省重点实验室,长沙410078,湖南

收稿日期:2008-03-13 修回日期:2008-03-25 出版日期:2008-04-26 发布日期:2020-10-12
通讯作者: 刘昭前,男,博士,教授,博士生导师,研究方向:遗传药理学和药物基因组学。Tel:0731-4805380 E-mail:liuzhaoqian63.@126.com
作者简介:周芳,女,硕士研究生,研究方向:遗传药理学。Tel:13077306610 E-mail:zhfang126com@126.com
基金资助:
国家自然科学基金(30572230);教育部新世纪优秀人才支持计划(NCET-04-0749)

Relationship between type 2 diabetes and retinol binding protein 4 and its genetic poly morphism

ZHOU Fang, ZHOU Hong-hao, LIU Zhao-qian

Institute of Clinical Pharmacology, Key laboratory of Pharmacogenetics in Hunan Province, Central South University,Changsha 410078,Hunan,China

Received:2008-03-13 Revised:2008-03-25 Online:2008-04-26 Published:2020-10-12

摘要/Abstract

摘要： 视黄醇结合蛋白( retinol hinding protein,RBP)属于视黄醇运载蛋白,其血清水平常作为临床营养状况、肝肾疾病的早期诊断和疗效的评价指标。最新研究发现:视黄醇结合蛋白4(RBP4)为一种新的脂肪源性信使,参与了胰岛素抵抗和2型糖尿病的发生。这一发现使得RBP4开始倍受关注。本文主要介绍视RBP4的结构、遗传多态性及其与2型糖尿病之间的最新研究进展。

关键词: 视黄醇结合蛋白4, 单核苷酸多态性, 2型糖尿病

Abstract: Retinol-binding potein ( RBP) is the primary transport protein for retionl. Serum plasma levels of RBP can serve as an index for detecting the development and the curative effects of the diseases of kindey and liver, as well as nutnitional diseases. Recent research reported that retinol binding protein 4(RBP4) is a newly discovered messenger fiom adipocyte, which plays a role in insulin resistance and obesity. The research and findings of the structure, gene polymorphism of RBP4, and association of RBP4 with type 2 diabetes ( T2DM) was reviewed in this article.

Key words: retinol binding protein 4, single nucleotide polymorphism, type 2 diabetes

中图分类号:

R589

周芳, 周宏灏, 刘昭前. 视黄醇结合蛋白4遗传多态性与2型糖尿病的关系[J]. 中国临床药理学与治疗学, 2008, 13(4): 452-456.

ZHOU Fang, ZHOU Hong-hao, LIU Zhao-qian. Relationship between type 2 diabetes and retinol binding protein 4 and its genetic poly morphism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(4): 452-456.

参考文献

[1] Blomhff R,Green MH,Berg T,et al. Transport and storage of vitamin A[J. Sdience,1990,250(4979):399-404.
[2] Aeberli I,Biebinger R,Lehmann R,et al. Seum retinolbinding protein 4 concentration and its ratio to serm retinol are associated with obesity and metabolic syndrome components in children[J]. J Clin Endoci nol Metab,2007,92(11):4359-4365.
[3] Isozaki M,Masubuchi Y,Horie T. Evaluation of drug; induced hepatotoxicity by plasma retiml binding protein[J].In lio,2002,16(1):61-65.
[4] 乔玉峰,庞东梓.糖尿病肾病早期诊断指标研究进展[J].国外医学泌尿系统分册,2005,25(5):670-672.
[5] Yang Q,Graham TE,Mody N,et al. Senum ret inol binding protein 4 contributes to insulin resistance in obesity and type2 diabetes[J].Nature,2005,436(7049):356-362.
[6] Graham TE,Yang Q,Bliher M,et al. Retinok binding protein 4 and insulin resistance in lean,obese,and diabetic subjet[J]. N Engl J Med,2006,354(24):2552-2563.
[7] 陈健,周度金.视黄醇类结合蛋白的分类结构及功能[J].生命的化学,2004,24(2):112-115.
[8] Naylor HM,Newcomer ME. The structure of human retinol-bingding protein whit its carrier protein transt hy retin reveals an intenaction with the carboxy teminus of RBP[J].Biochemistry,1999,38(9):2647-2653.
[9] 陈健,陈敏,陈彬,等.视黄醇结合蛋白RBP4可与多种核受体相互作用[J].中国生物化学与分子生物学报,2004,20(5):696-701.
[10] 梁学颖,徐琪寿.视黄醇结合蛋白的分子生物学[J].生理科学进展,2000,31(3):277-279.
[11] Munkhtulga L,Nakay ama K,Utsumi N,et al. Identification of a regulatory SNP in the retinol binding protein 4gene associated with type 2 diabetes in Mongolia[J]. Hum Genet,2007,120(6):879-888.
[12] Craig RL,Chu WS,ElbeinSC. Retinol bindi ng protein 4 as a candidate gene for type 2 diabetes and prediabetic intemediate traits[J]. Mol Genet Metab,2007,90(3):338.
[13] 吴海娅,贾伟平,魏丽,等.肥胖及2型糖尿病患者血清视黄醇结合蛋白4水平的变化及其临床意义[J].中华内分泌代谢杂志,2006,22(30):290-293.
[14] Graham TE,Yang Q,Bliher M,et al. Reti nok Binding Prtein 4 and Insulin Resistance in Lean,Obese,and Diabetic Subjects[J]。N Engl J Med,2006,354(24):2552-2563.
[15] Khting N,Graham TE,Bemdt J,et al. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra abdominal fat mass[J]. Cell Metab,2007,6(1):79-87.
[16] Stefan N,Hennige AM,Staiger H,et al. High circulating ret inot binding protein 4 is associated with elevated liver fat but not w ith total,subcutaneous,visceral,or intramyo cellularfat in humans[J].Diabetes Care,2007,30(5):1173-1178.
[17] Cho YM,Youn BS,Lee H,et al. Plama retinol binding protein4 concent rations are elevated in human sub jects with impaired glucose tolerance and type 2 diabetes[J].Diabetes Care,2006,29(11):2457-2461.
[18] Jia W,WuH,Bao Y,et al. Association of serum retinol-binding protein 4 and visceral adi posity in Ch inese sub jects with and without type 2 diabetes[J].J Clin Endocrinol Metab,2007,92(8):3224-3229.
[19] Yao Borengasser A,Vamma V,Bodles AM,et al. Retinol bindi ng protein 4 expression in humans:relationship to in sulin resistance,inf lammation,and lesponse to pioglita zone[J]. J Clin Endocrinol Metab,2007,92(7):2590-2597.
[20] Munkhtulga L,Nakayama K,Utsumi N,et al. Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia[J]. Hum Genet,2007,120(6):879-888.
[21] Craig RL,Chu WS,Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intemediate traits[J].Mol Genet Metab,2007,90(3):338-344.
[22] Hu C,Jia W,Zhang R,et al. Efect of RBP4 gene variants on circulating RBP4 concentration and Type 2 diabetes in a Chinese population[J].Diabet Med,2008,25(1):11-18.