活血通窍贴片经皮给药对兔急性脑出血血液流变学及超氧化物歧化酶、丙二醛的影响

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (7): 772-775.

活血通窍贴片经皮给药对兔急性脑出血血液流变学及超氧化物歧化酶、丙二醛的影响

赵清超, 胡久略

南阳理工学院张仲景国医学院, 南阳 473004, 河南

收稿日期:2008-01-13 修回日期:2008-06-27 出版日期:2008-07-26 发布日期:2020-10-14
作者简介:赵清超,本科,工程师,主要从事教学、药物制剂、药理实验研究及新药开发。Tel:0377-62071308 E-mail:zqc8456@163.com

Effect of Huoxuetongqiao patch in transdermal delivery on hemorheology indics and SOD and LPO in experimental cerebral hemorrhage rabbits

ZHAO Qing-chao, HU Jiu-lue

Zhangzhongjing College of TCM of Nanyang Institute of Technology, Nanyang 473004, Henan, China

Received:2008-01-13 Revised:2008-06-27 Online:2008-07-26 Published:2020-10-14

摘要/Abstract

摘要： 目的:探讨磁场作用下活血通窍贴片经皮给药治疗兔急性脑出血的作用机理。方法:以日本大耳白兔为研究对象,随机分成正常对照组、模型组、药物组和磁场下药物组。其中,药物组仅经皮给予活血通窍中药贴片,含磁药物组经皮给予活血通窍贴片。分别测血液流变学指标及脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)含量。结果:与正常对照组比较,模型组全血低切黏度、全血高切黏度、红细胞压积、红细胞聚集指数均普遍降低(P<0.05或P<0.01),血浆黏度升高(P<0.01);与模型组比较,药物组和含磁药物组全血低切黏度、全血高切黏度、红细胞压积升高(P<0.05或P<0.01),血浆黏度明显降低(P<0.05),其中含磁药物组更为显著。此外,模型组脑组织SOD含量较正常对照组显著降低(P<0.01),MDA含量较正常对照组显著增高(P<0.01);与模型组相比,药物组和含磁药物组SOD含量明显增高(P<0.05或P<0.01),MDA含量显著降低(P<0.01),其中含磁药物组更为显著。结论:活血通窍贴片经皮给药能显著改善兔急性脑出血血液流变性,提高SOD含量,降低MDA含量,这可能是活血通窍贴片治疗脑出血的部分作用机理。

关键词: 活血通窍贴片, 脑出血, 血液流变学, 超氧化物歧化酶, 丙二醛

Abstract: AIM: To study the mechanism of Huoxuetongqiao patch in transdermal delivery andmagnetic field on experimental cerebral hemorrhage rabbits.METHODS: The cerebral hemorhage model rabbits were randomly divided into four groups: normal control group, model group, herbs group and herbs in magnetic field group.The normal control group and the model group were not treated.The herbs group were given Huoxuetongqiao herbs.Herbs in magnetic field group were given Huoxuetongqiao patch in the magnetic field.Hemorheology indices and SOD and MDA were detected respectively.RESULTS: Most of the hemorheology indices significantly decreased compared with those in normal control group.And one hour later, the main indices of hemorheology indices decreased below the normal level.In addition, the content of SOD obviously decreased and the content of MDA inmodel croup increased compared with those of normal control group (P<0.01).Compared with model group, the content of SOD increased and the content of MDA was obviously decreased in herbs group and herbs in magnetic field group (P<0.01 or P<0.05).Otherwise, those of herbs in magnetic field group were more significant compared with herbs group.CONCLUSION: Huoxuetongqiao patch can obviously improve the hemorheology of rabbits with cerebral hemorrhage, increase the content of SOD and induce the content of MDA.These may be the partial mechanisms of patch on experiment cerebral hemorrhage rabbits.

Key words: Huoxuetongqiao patch, cerebral hemorrhage, hemorheology, SOD, MDA

中图分类号:

R965.2

赵清超, 胡久略. 活血通窍贴片经皮给药对兔急性脑出血血液流变学及超氧化物歧化酶、丙二醛的影响[J]. 中国临床药理学与治疗学, 2008, 13(7): 772-775.

ZHAO Qing-chao, HU Jiu-lue. Effect of Huoxuetongqiao patch in transdermal delivery on hemorheology indics and SOD and LPO in experimental cerebral hemorrhage rabbits[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(7): 772-775.

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