缺血性中风治疗新策略——靶向神经血管单元

摘要/Abstract

摘要： 近20年来,对缺血性中风发生后脑细胞不可逆损伤的机制进行了大量的研究,重点探讨了导致神经元死亡的原因以及使神经元抵御死亡的策略。应用溶栓药物的临床经验已经证明早期的再灌注能够改善缺血症状。近来的研究着眼于通过血管和细胞机制来减轻组织损伤,研究血管系统与大脑细胞之间如何相互通讯。基于对血管和神经系统的功能认识,形成了神经血管单元(neurovascular unit)的概念。这一新的研究焦点为中风的研究和治疗带来了新的机遇和挑战。

关键词: 中风, 神经血管单元, 血脑屏障, 基质金属蛋白酶

Abstract: Over the past two decades, researches have heavily emphasized on basic mechanisms of irreversible damage in brain cells after stroke.Many studies focused on what makes neurons die easily and what kind of strategies render neurons resistant to ischemic injury.In the past few years, clinical experience with clot-lysing drugs had confirmed expectations that early reperfusion improves clinical outcome.With recent research emphasizing methods to reduce tissue damage, both vascular and cell-based mechanisms, the spotlight is now shifting towards the study of how blood vessels and brain cells communicate with each other.The neurovascular unit (NVU) origins from an integrative blood vessel and neural system response in which all cellular and matrix elements involved in.The new research focus provides challenges and opportunities for research and therapy of stroke.

Key words: stroke, neurovascular unit, blood brain barrier, MMPs

中图分类号:

高梅, 刘睿, 杜冠华. 缺血性中风治疗新策略——靶向神经血管单元[J]. 中国临床药理学与治疗学, 2008, 13(7): 813-821.

GAO Mei, LIU Rui, DU Guan-hua. Therapeutic strategies for stroke: targeting the neurovascular unit[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(7): 813-821.

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