胃泌素在胃肠道肿瘤中的作用及其信号转导途径的研究进展

中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (7): 822-827.

胃泌素在胃肠道肿瘤中的作用及其信号转导途径的研究进展

潘峻涛, 吴佩

皖南医学院弋矶山医院普外一科, 芜湖 241001, 安徽

收稿日期:2008-03-28 修回日期:2008-04-25 出版日期:2008-07-26 发布日期:2020-10-14
通讯作者: 吴佩,男,主任医师,教授,硕士研究生导师,研究方向:胃肠外科。Tel:0553-5739343 E-mail:wp5708@sina.com
作者简介:潘峻涛,男,在读硕士研究生,研究方向:胃肠外科。Tel:0553-5739343 E-mail:panjuntao1@126.com
基金资助:
安徽省教育厅自然科学基金(2006kj115c)

Advancement of research on the role and signal transduction pathway of gastrin in gastroenteric tumor

PAN Jun-tao, WU Pei

Department of General Surgery, Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China

Received:2008-03-28 Revised:2008-04-25 Online:2008-07-26 Published:2020-10-14

摘要/Abstract

摘要： 胃泌素对于胃肠道肿瘤的促进作用已经被很多研究所证实。胃泌素与细胞表面受体结合后,通过一定的信号转导途径来调节某些基因转录与表达,从而促进肿瘤发生与发展。通过对胃泌素在胃肠道肿瘤中作用机制及其信号转导途径研究,有望找到更有效的胃肠道肿瘤治疗方法。

关键词: 胃泌素, 受体, 信号转导, 黏着斑激酶(FAK)

Abstract: Studies have proved that gastrin plays key roles in the development and progression of gastroenteric tumor.After gastrin combined with the tumor cell surface receptors, some genetic transcription and expression were adjusted through certain signal transduction pathways, resulting in the development and growth of gastrointestinal carcinoma.Effective treatment method would been founded about gastroenteric tumor through the studies of mechanism of action and signal transduction pathways of gastrin in gastroenteric tumor.

Key words: gastrin, receptor, signal transduction, focal adhesion kinase (FAK)

中图分类号:

R735

潘峻涛, 吴佩. 胃泌素在胃肠道肿瘤中的作用及其信号转导途径的研究进展[J]. 中国临床药理学与治疗学, 2008, 13(7): 822-827.

PAN Jun-tao, WU Pei. Advancement of research on the role and signal transduction pathway of gastrin in gastroenteric tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(7): 822-827.

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