天然香豆素的抗癌机制研究进展

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (10): 1174-1177.

天然香豆素的抗癌机制研究进展

吴龙火, 李培, 刁勇, 许瑞安

华侨大学分子药物学研究所&分子药物教育部工程研究中心, 泉州 362021, 福建

收稿日期:2009-06-15 修回日期:2009-07-16 发布日期:2020-10-29
通讯作者: 许瑞安,男,博士生导师,研究方向:主要从事分子药物、分子药理学及医学生物工程技术研究。Tel:0595-22690592 E-mail:ruianxu@hqu.edu.cn
基金资助:
华侨大学校基金资助项目(06y0045)

Progress on anti-cancer mechanisms of natural coumarins

WU Long-huo, LI Pei, DIAO Yong, XU Rui-an

Institute of Molecular Medicine, HuaqiaoUniversity & Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou 362021, Fujian, China

Received:2009-06-15 Revised:2009-07-16 Published:2020-10-29

摘要/Abstract

摘要： 已有许多研究报道天然香豆素具有抗癌活性, 它的抗癌机制与其具有的多项生理调节作用有关。本文从对细胞周期的影响、诱导细胞凋亡、SAPK JNK p38MAP 等信号通路及对GSH 转硫酶NADPH醌氧化还原酶(GST NQO)体系的影响等方面对天然香豆素的抗癌机制进行简要综述。

关键词: 香豆素, 抗癌机制, 细胞周期, 凋亡, 信号通路

Abstract: Many literatures on anti-cancer activities of natural occurring coumarins are available.The anti-cancer mechanisms of coumarins are related to the physiological modulations in the living body.This paper is aimed to review the anti-cancer mechanisms of coumarins from different aspects such as influences on cell cycles, induction of cell apoptosis, SAPK JNK p38MAP signaling pathways and the system of glutathione S-transferases (GST) NADPH quinine oxidoreductase (NQO).

Key words: coumarins, anti-cancer mechanism, cell cycles, apoptosis, signaling pathways

中图分类号:

R966

吴龙火, 李培, 刁勇, 许瑞安. 天然香豆素的抗癌机制研究进展[J]. 中国临床药理学与治疗学, 2009, 14(10): 1174-1177.

WU Long-huo, LI Pei, DIAO Yong, XU Rui-an. Progress on anti-cancer mechanisms of natural coumarins[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(10): 1174-1177.

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