膜蛋白与膜蛋白组学

摘要/Abstract

摘要： 膜蛋白是指能够结合或整合到细胞或细胞器的膜上的蛋白质的总称。现在市场上销售的药物80 %以上都是作用在膜蛋白上的, 膜蛋白是理想的药物靶点, 因此, 对膜蛋白的研究具有十分重要意义。但由于膜蛋白的溶解、分离、鉴定十分困难, 造成膜蛋白组学研究的滞后。本文就膜蛋白的结构, 膜蛋白在细胞生理和人类疾病中扮演的重要角色, 膜蛋白作为药物靶点的潜力以及膜蛋白组学研究技术作一综述。

关键词: 膜蛋白, 膜蛋白组学, 药物靶点

Abstract: A membrane protein is a protein molecule that is attached to, or integrated into the membrane of a cell or an organelle.As the membrane protein is a good target for drugs, more than 80 % of the drugs on the present market take the effect on the membrane protein.Therefore, it is significant to study the membrane proteins.However, the traditional study on membrane proteomics is obstructed by the difficulties in solubilizing, separating, and identifying membrane proteins.This review summarizes the structure of membrane proteins, the significant role of the membrane proteins on the cell physiology and the human diseases, the potential of the membrane proteins to be the target for drugs and the techniques of the research on the membrane proteomics.

Key words: membrane proteins, membrane proteomics, drug target

中图分类号:

R966

梁燕, 阚红卫, 杨士友. 膜蛋白与膜蛋白组学[J]. 中国临床药理学与治疗学, 2009, 14(11): 1313-1320.

LIANG Yan, KAN Hong-wei, YANG Shi-you. Membrane proteins and membrane proteomics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(11): 1313-1320.

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