人组织激肽释放酶对周围神经系统损伤后的修复效应

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (12): 1351-1355.

人组织激肽释放酶对周围神经系统损伤后的修复效应

刘珺¹, 王均炉¹, 胡祥鹏², 厉彩霞³, 彭玲莉¹

¹温州医学院附属第一医院麻醉科, 温州 325000, 浙江;
²温州医学院附属第一医院消化内科, 温州 325000, 浙江;
³浙江大学附属第一医院麻醉科, 杭州 310003, 浙江

收稿日期:2009-10-12 修回日期:2009-11-06 发布日期:2020-10-20
通讯作者: 王均炉,男, 本科, 主任医师, 教授, 硕士生导师, 研究方向:围术期重要器官保护。Tel:0577-88069458 E-mail:wangjunlu@yahoo.com.cn
作者简介:刘珺, 女, 硕士研究生, 研究方向:围术期重要器官保护。Tel:0577-88069458 　E-mail:liujun841030@yahoo.com.cn

Effect of human tissue kallikrein on peripheral nerve injury

LIU Jun¹, WANG Jun-lu¹, HU Xiang-peng², LI Cai-xia³, PENG Ling-li¹

¹Department of Anesthesiology, First Hospital, WenzhouMedical College, Wenzhou 325000, Zhejiang, China;
²Department of Gastroenterology, First Hospital, WenzhouMedical College, Wenzhou 325000, Zhejiang, China;
³Department of Anesthesiology, First Hospital, Zhejiang University, Hangzhou 310003, Zhejiang, China

Received:2009-10-12 Revised:2009-11-06 Published:2020-10-20

摘要/Abstract

摘要： 目的：评价人组织激肽释放酶( HTK) 促进周围神经系统损伤后的修复作用。方法：取30 只体重180 ~ 200 g 的雄性SD 大鼠, 随机分成3 组:假手术组、HTK 组( 17.5 ×10^-3 PNAU kg) 、对照组, 每组各10 只。术前第0 天和术后第1 、第3 、第5 、第7 、第9 、第11 、第13 天测定坐骨神经功能指数( SFI) 以及静止坐骨神经指数( SSI), 术后第14 天测定坐骨神经干动作电位传导速度( NCV) 。结果：SFI 、SSI 值在假手术组手术前后未见明显改变。HTK 组和对照组中, 术后第1 天SFI 、SSI 均为-100 左右。以后发现HTK 组的SFI 、SSI 恢复的情况要优于对照组, 从第5 天开始两组SFI 、SSI 值有统计学差异( P <0.05) 。术后第14 天HTK 组的NCV 值要高于对照组, 两组间有统计学差异( P <0.05) 。结论：HTK 具有促进周围神经系统损伤后的修复作用。

关键词: 人组织激肽释放酶, 周围神经损伤, 坐骨神经功能指数, 静止坐骨神经指数, 神经干动作电位传导速度

Abstract: AIM: To verify the therapeutic effection of human tissue kallikrein( HTK) on peripheral nervous system regeneration.METHODS: 30 adult male SD rats weighted 180 -200 g were randomly divided into 3 groups:Sham group, HTK group( 17.5 ×10^-3PNAU kg), Control group( n =10).Calculating sciatic functional index (SFI) and static sciatic index ( SSI) were performed on the day before nerve crushed and day 1, 3, 5, 7, 9, 11, 13 after operation in all rats.The electrophysiological results of the sciatic nerve was determined on the 14th day postoperation.RESULTS: There was no apparent functional deficit in the Sham group before and after operation.The HTK group showed a statistically significant improvement over the control group on the 5th day postoperation.The NCV of the HTK group was greater than the Control group ( P <0.05).CONCLUSION: The treatment of HTK is effective on peripheral nervous system regeneration.

Key words: human tissue kallikrein, peripheral nervous system injury, sciatic functional index, static sciatic index, nerve conduction velocity

中图分类号:

R965.2

刘珺, 王均炉, 胡祥鹏, 厉彩霞, 彭玲莉. 人组织激肽释放酶对周围神经系统损伤后的修复效应[J]. 中国临床药理学与治疗学, 2009, 14(12): 1351-1355.

LIU Jun, WANG Jun-lu, HU Xiang-peng, LI Cai-xia, PENG Ling-li. Effect of human tissue kallikrein on peripheral nerve injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(12): 1351-1355.

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