亚硒酸钠联合泼尼松治疗亚急性甲状腺炎临床观察

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (12): 1400-1402.

亚硒酸钠联合泼尼松治疗亚急性甲状腺炎临床观察

夏礼斌, 陆美琴, 张斌华, 张安素, 陈月平, 赵咏莉, 华强, 何春玲

皖南医学院弋矶山医院内分泌科, 芜湖 241000, 安徽

收稿日期:2009-10-26 修回日期:2009-11-29 发布日期:2020-10-20
作者简介:夏礼斌, 男, 副主任医师, 研究方向:内分泌与免疫。Tel:13955315538 E-mail:xialibin0929@yahoo.com.cn

Clinical observation of sodium selenite combination prednisone treatment on subacute thyroiditis

XIA Li-bin, LU Mei-qin, ZHANG Bin-hua, ZHANG An-su, CHEN Yue-ping, ZHAO Yong-li, HUA Qiang, HE Chun-ling

Department of Endocrinology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui, China

Received:2009-10-26 Revised:2009-11-29 Published:2020-10-20

摘要/Abstract

摘要： 目的：探讨亚硒酸钠联合泼尼松对亚急性甲状腺炎患者的影响。方法：对2004 年9 月-2008 年8 月在本院诊治的78 例亚甲炎患者进行随机对照前瞻性研究。对照组有2 例失访, 37 例完成观察, 治疗组39 例。两组均予以泼尼松治疗(30 mg/d), 治疗组加服亚硒酸钠, 总疗程8 周左右。结果：经过8 周治疗, 第2 、4 周亚硒酸钠组的血沉低于对照组( P <0.05), 亚硒酸钠组2 h 、6 h和24 h 吸碘率的高于对照组( P <0.01), 而复发率低于对照组( P <0.05) 。结论：亚硒酸钠可以缩短亚急性甲状腺炎病程, 减少复发率。

关键词: 亚硒酸钠, 亚急性甲状腺炎, 血沉, ¹³¹I 摄取率

Abstract: AIM: To investigate the effects of sodium selenite combination prednisone in patients with subacute thyroiditis( SAT).METHODS: 78 cases of SAT were studied with a randomized controlled prospective study from Sep 2004 to Aug 2008 in our hospital.In control group, 2 cases were lost, 37 patients were completed the observation, the treatment group were 39 cases.Prednisone was treated in both groups, sodium selenite was served in treatment group, with a total course of about 8 weeks.RESULTS: After 8 weeks of treatment, the erythrocyte sedimentation rate ( ESR) of sodium selenite group was lower than that of control group at 2th and 4th weeks ( P <0.05), ¹³¹ I uptake rate of sodium selenite group was higher than that of control group at 2 h, 6 h and 24 h ( P < 0.01), while the relapse rate was lower than that of the control group ( P <0.05).CONCLUSION: The sodium selenite can shorten the course of subacute thyroiditis and reduce the relapse rate.

Key words: sodium selenite, subacute thyroiditis(SAT), erythrocyte sedimentation rate ( ESR), ¹³¹I uptake rate

中图分类号:

R581

夏礼斌, 陆美琴, 张斌华, 张安素, 陈月平, 赵咏莉, 华强, 何春玲. 亚硒酸钠联合泼尼松治疗亚急性甲状腺炎临床观察[J]. 中国临床药理学与治疗学, 2009, 14(12): 1400-1402.

XIA Li-bin, LU Mei-qin, ZHANG Bin-hua, ZHANG An-su, CHEN Yue-ping, ZHAO Yong-li, HUA Qiang, HE Chun-ling. Clinical observation of sodium selenite combination prednisone treatment on subacute thyroiditis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(12): 1400-1402.