Nampt/Visfatin/PBEF 研究进展

摘要/Abstract

摘要： 尼克酰胺磷酸核糖转移酶(nicotinamide phosphoribosyltransferase, Nampt)是生物合成NAD的关键限速酶, 又被称为前B 细胞克隆增强因子(pre-B cell colony enhancing factor, PBEF)和内脏脂肪素(visfatin)。最近研究发现, Nampt/Visfatin/PBEF 在NAD 生物合成、代谢、炎症反应和细胞增殖、分化、凋亡等诸多领域发挥作用, 可能影响2型糖尿病、急性肺损伤、恶性肿瘤等疾病发生、发展和预后。本文主要对Nampt/Visfatin/PBEF 的生理功能及临床意义进行综述。

关键词: 烟酰胺磷酸核糖转移酶, 前B 细胞克隆增强因子, 内脏脂肪素

Abstract: Nicotinamide phosphoribosy ltransferase (Nampt)is the crucial rate-limiting enzyme of NAD biosynthesis, also known as pre-B cell colony-enhancing factor (PBEF) and visfatin.Recently, it has been found that Nampt/Visfatin/PBEF plays a role in many fields like NAD biosynthesis, metabolism and inflammatory response, as well as cell proliferation, differentiation and apoptosis.Nampt/Visfatin/PBEF might affect the development and prognosis of diseases such as type 2 diabetes, pulmonary diseases, malignant tumors and so on.This paper focuses on the physiological function and clinical significance of Nampt/Visfatin/PBEF.

Key words: nicotinamide phosphoribosyltransferase, pre-B cell colony enhancing factor, visfatin

中图分类号:

R969

盛飞凤, 刘昭前. Nampt/Visfatin/PBEF 研究进展[J]. 中国临床药理学与治疗学, 2009, 14(12): 1423-1427.

SHENG Fei-feng, LIU Zhao-qian. Research progress of Nampt Visfatin PBEF[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(12): 1423-1427.

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