关键词: 紫菀, 款冬花, 中药配伍, 抗炎

Abstract: AIM: To investigate the anti-inflammatory effects of the mixture of the active parts of Radix Asteris (RA) and Flos Farfarae (FF) (1∶1, w/w) and analyze the relation of compatibility between them. METHODS: The anti-inflammatory effects were measured by inhibiting the nitric oxide synthesis in LPS-ac-tivated macrophageshe, inhibitioning of capillary permeability inmice and acute airway inflammation caused by centrated ammonia method in mice.RESULTS: Compared with two individual active parts, the mixture playded a more prominent role in inhibition of capillary permeability in mice (inhibition ratio :45.1 %, 45.3 %, 51.8 %) and acute airway inflammation caused by centrated ammonia method in mice (inhibition ratio :48.0 %, 53.4 %, 61.4 %);furthermore, the same result resided in RA2, FF3 and their mixture in inhibition of nitric oxide synthesis in LPS-activated macrophageshe(P <0.05 or P <0.01).CONCLUSION: The mixture of two active parts of RA and FF can significantly strengthen the anti-inflammatory effect of two individual active parts, indicating that the mixture of two active parts is provided with mutual promotion effect.

Key words: Radix Asteris, Flos Farfarae, compatibility of CTM, anti-inflammatory