钠钙交换体及其抑制剂在脑缺血中的作用

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (2): 237-240.

• 综述与讲座 • 上一篇

钠钙交换体及其抑制剂在脑缺血中的作用

曾雯君¹, 沈磊², 吴玉林²

¹宁波市海曙区段塘街道社区卫生服务中心, 宁波315012, 浙江;
²中国药科大学生理教研室, 南京210009, 江苏

收稿日期:2008-07-17 修回日期:2009-02-16 出版日期:2009-02-26 发布日期:2020-10-30
通讯作者: 吴玉林, 男, 博士, 副教授, 硕士生导师, 研究方向:心血管药理学。Tel:13809001236 　E-mail:wylcpu@yahoo.com.cn
作者简介:曾雯君, 女, 本科, 主管药师。Tel:13806679246 　E-mail:xldongqx@tam.com

Effects of sodium-calcium exchanger and its inhibitors on cerebral ischemia

ZENG Wen-jun¹, SHEN Lei¹, WU Yu-lin²

¹Duantang Neighborhood Community Health Center, HaishuDistrict, Ningbo 315012, Zhejiang, China;
²Division of Physiological Research, China Pharmaceutical University, Nanjing 210009, Jiangsu, China

Received:2008-07-17 Revised:2009-02-16 Online:2009-02-26 Published:2020-10-30

摘要/Abstract

摘要： 在神经细胞中, 钠钙交换体对胞内钙离子的调控起着非常重要的作用。缺血/再灌注使细胞外的钙通过钠钙交换体的反向模式内流, 造成内钙超载, 导致脑细胞损伤。现今, 选择性抑制其反向模式的苄氧基苯基衍生物得到了较多的研究, 并可能成为一个新的治疗脑缺血的有潜力靶点。

关键词: 钠钙交换体, 反向模式, 钙超载, 钠钙交换体抑制剂, 脑缺血/再灌注

Abstract: In neural cell, Na⁺/Ca²⁺ exchanger (NCX)is thought to play an important role in the regulation of intracellular Ca²⁺ concentration.During the cerebral ischemia/reperfusion, the influxion of Ca²⁺ though NCX reverse mode induce calcium overload, which make neural cell damage.Recently, the benzyloxyphenyl derivatives have been developed as selective NCX inhibitors, which may have therapeutic potential as a new remedy for cerebral ischemia.

Key words: Na⁺/Ca²⁺ exchanger, reverse mode, calcium overload, Na⁺/Ca²⁺ exchanger inhibitor, ischemia/reperfusion

中图分类号:

R743

曾雯君, 沈磊, 吴玉林. 钠钙交换体及其抑制剂在脑缺血中的作用[J]. 中国临床药理学与治疗学, 2009, 14(2): 237-240.

ZENG Wen-jun, SHEN Lei, WU Yu-lin. Effects of sodium-calcium exchanger and its inhibitors on cerebral ischemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(2): 237-240.

参考文献

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钠钙交换体及其抑制剂在脑缺血中的作用

Effects of sodium-calcium exchanger and its inhibitors on cerebral ischemia

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