氧化应激在糖尿病视网膜病发病机制中的研究进展

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (3): 356-360.

• 药物治疗学 • 上一篇

氧化应激在糖尿病视网膜病发病机制中的研究进展

薛嘉睿, 郎平, 吴昌凡

皖南医学院附属弋矶山医院眼科, 芜湖241001, 安徽

收稿日期:2008-11-28 修回日期:2008-11-28 发布日期:2020-10-27
通讯作者: 郎平,女, 副教授, 硕士生导师, 研究方向:眼底病学。Tel:13966039369 E-mail:cfwu18@yahoo.com.cn
作者简介:薛嘉睿, 女, 在读研究生, 研究方向:眼底病学。Tel:13805534539 E-mail:miao79 @126.com

Research progress of oxidative stress in the pathogenesis of diabetic retinopathy

XUE Jia-rui, LANG Ping, WU Chang-fan

Department of Ophthalmology, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China

Received:2008-11-28 Revised:2008-11-28 Published:2020-10-27

摘要/Abstract

摘要： 糖尿病视网膜病是糖尿病最常见和严重的微血管并发症之一。近年来大量研究表明, 氧化应激和糖尿病视网膜病变的发生发展有一定的相关性。高血糖引起体内氧化应激反应, 氧化应激又通过损害内皮细胞、线粒体, 生成异常代谢通路, 促进炎性反应等加重对视网膜组织的损害, 造成视网膜缺血、甚至脱离等严重后果;而抗氧化治疗在临床上也取得了一定的成效。本文主要围绕氧化应激和糖尿病视网膜病的发病关系展开综述。

关键词: 氧化应激, 糖尿病视网膜病, 活性氧簇

Abstract: Diabetic retinopathy is one of the most common and serious chronic complications.Recently, great quantities of researches show that there are correlations between the oxidative stress and the diabetic retinopathy.Hyperglycemia causes the oxidative stress, and it damages the retina through injuring the endothelial cells and mitochondria, generating abnormal metabolism pathway and promoting the inflammatory response, then the serious consequences have been caused such as retinal ischemia or even detachment.In clinic the antioxidant treatment has achieved some results.So this paper focuses on the relationship of the oxidative stress and the incidence of the diabetic retinopathy.

Key words: oxidative stress, diabetic retinopathy, reactive oxygen species

中图分类号:

R774

薛嘉睿, 郎平, 吴昌凡. 氧化应激在糖尿病视网膜病发病机制中的研究进展[J]. 中国临床药理学与治疗学, 2009, 14(3): 356-360.

XUE Jia-rui, LANG Ping, WU Chang-fan. Research progress of oxidative stress in the pathogenesis of diabetic retinopathy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 356-360.

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氧化应激在糖尿病视网膜病发病机制中的研究进展

Research progress of oxidative stress in the pathogenesis of diabetic retinopathy

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