布洛伪麻那敏片与氨酚伪麻那敏片治疗上呼吸道症状的对照研究

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (8): 928-932.

布洛伪麻那敏片与氨酚伪麻那敏片治疗上呼吸道症状的对照研究

薛成¹, 蒋静涵¹, 王伟华¹, 张建初², 熊盛道³, 张伟⁴, 刘纯⁵

¹皖南医学院弋矶山医院急诊内科 ,芜湖 241000, 安徽;
²华中科技大学同济医学院附属协和医院呼吸科, 武汉 430033,湖北;
³华中科技大学同济医学院附属同济医院呼吸科,武汉 430033,湖北;
⁴南昌大学第一附属医院呼吸科,南昌 430000,江西;
⁵中南大学湘雅三医院呼吸科,长沙 410000,湖南

收稿日期:2008-11-19 修回日期:2009-05-27 出版日期:2009-08-26 发布日期:2020-10-30

A Controlled study on ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets and paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets in the treatment of upper respiratory tract infection

XUE Cheng¹, JIANG Jing-han¹, WANG Wei-hua¹, ZHANG Jian-chu², XIONG Sheng-dao³, ZHANGWei⁴, LIU Chun⁵

¹Department of Emergency Internal Medicine , Yijishan Hospital of Wannan Medical College , Wuhu241000 , Anhui ,China;
²Breath Internal Medicine , Affiliated Union Hospital of Tongji Medical College , Huazhong University of Sci-ence and Technology , Wuhan 430033 , Hubei , China;
³Breath Internal Medicine , Affiliated Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan430033 , Hubei , China;
⁴Breath Internal Medicine , the First Affiliated Hospital of Nanchang University , Nanchang 430000 , Jiangxi , China;
⁵Breath Internal Medicine , the Third Xiangya Hospital of Central South University , Changsha 410000 , Hunan , China

Received:2008-11-19 Revised:2009-05-27 Online:2009-08-26 Published:2020-10-30

摘要/Abstract

摘要： 目的: 评价布洛伪麻那敏片治疗由普通感冒或感冒所致的上呼吸道症状的有效性和安全性。方法: 采用多中心、随机双盲、阳性药物平行对照研究。共完成的病例数为 226 例。其中A 组112 例, B 组 114 例 , 分别予以布洛伪麻那敏片和氨酚伪麻那敏片治疗 ,药物用法为每日 3 次, 每次1 片, 疗程 3 ~ 5 d。结果: A 组的总有效率为100.00%,总显效率为 98.21%;B 组的总有效率为 99.12%,总显效率为 97.37%。表明 A 组和 B组总疗效差异无统计学意义(P>0.05)。两组总有效率和总显效率非劣效性检验显示 ,A 组非劣效于 B 组(P <0.05)。不良反应发生率,A 组和 B组分别为 20.18%和 24.79%(P>0 .05)。结论: 布洛伪麻那敏片和氨酚伪麻那敏片均系对症治疗感冒所致上呼吸道症状的安全有效药物。

关键词: 布洛伪麻那敏片, 氨酚伪麻那敏片, 感冒

Abstract: AIM: To evaluate the efficacy and safety of ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets for the treatment of upper respiratory tract infection. METHODS: A multi-center,double-blind, randomizde controlled and positive drug parallel trial was conducted.226 patients were enrolled and divided into two groups.Group A (112 cases)were treated with ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets and Group B (114 cases)were treated with paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets.The method to take the medicine was one tablet three times a day for 3-5d.RESULTS: The total efficacy rate of Group A was 100%,with the total obvious effective rate of 98.21%;while the efficacy rate and the total obvious effective rate of Group B were 99.12%and 97.37% respectively .The results indi-cate that the difference between the efficacy rates of the 2 groups had no statistical significance (P>0.05). The occurrence rate of the adverse reaction in Group A and Group B was 20.18% and 24.79% respectively (P>0.05).CONCLUSION: Both ibuprofen pseudo-ephedrine hydrochloride and chlorpheniramine Maleate tablets and paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets are safe and effec-tive medicine in the treatment of upper respiratory symptoms caused by cold.

Key words: ibuprofen pseudoephedrine hydro-chloride and chlorpheniramine Maleate tablets, parac-etamol pseudoephedrine hydrochloride and chlorphena-mine maleate tablets, cold

中图分类号:

R511.6

薛成, 蒋静涵, 王伟华, 张建初, 熊盛道, 张伟, 刘纯. 布洛伪麻那敏片与氨酚伪麻那敏片治疗上呼吸道症状的对照研究[J]. 中国临床药理学与治疗学, 2009, 14(8): 928-932.

XUE Cheng, JIANG Jing-han, WANG Wei-hua, ZHANG Jian-chu, XIONG Sheng-dao, ZHANGWei, LIU Chun. A Controlled study on ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets and paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets in the treatment of upper respiratory tract infection[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(8): 928-932.

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