瑞舒伐他汀对慢性心力衰竭患者血清中细胞因子浓度的影响

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (10): 1152-1155.

瑞舒伐他汀对慢性心力衰竭患者血清中细胞因子浓度的影响

胡立群, 章琦, 陈莉, 李红旗, 尹长森

安徽医科大学附属安徽省立医院安徽省心血管病研究所,合肥 230001,安徽

收稿日期:2010-08-31 修回日期:2010-10-13 发布日期:2020-09-16
作者简介:胡立群,主任医师,教授,研究方向:老年心血管病。Tel: 13605513017 E-mail: hlq1963@163.com
基金资助:
安徽省卫生厅临床医学研究项目(2008B023)

Effects of rosuvastatin on serum soluble cell adhesion molecule levels in patients with chronic heart failure

HU Li-qun, ZHANG Qi, CHEN Li, LI Hong-qi, YI Chang-sen

Department of Cardiovasology Anhui Medical University Affliated Anhui provincial Hospital, Anhui Provincial Research Institute of Angiocardiopathy, Hefei 230001, Anhui, China

Received:2010-08-31 Revised:2010-10-13 Published:2020-09-16

摘要/Abstract

摘要： 目的: 观察瑞舒伐他汀短期治疗对慢性心力衰竭(chronic heart failure,CHF)患者血清中可溶性选择素-E(sE- selectin)和P(sP- selectin)水平的影响。方法: 70例CHF患者随机分为常规治疗组和干预组,常规治疗组给予强心、利尿、扩血管治疗,干预组在此基础上加用瑞舒伐他汀10 mg /晚,治疗4周。采用ELISA测定其治疗前后血清中sE- selectin和sP- selectin水平。结果: 心功能Ⅳ级患者血清sE-selectin和sP-selectin明显高于心功能Ⅱ、Ⅲ级患者(P<0.01),而心功能Ⅱ、Ⅲ级组间比较差异无统计学意义(P>0.05)。两组治疗后血清sE-selectin和sP-selectin水平均较治疗前有显著下降(P<0.05 或P<0.01),干预组sE-selectin下降水平优于常规治疗组 (P<0.05),而sP-selectin水平组间比较差异无统计学意义(P>0.05)。结论: 随着心功能恶化sE-selectin和sP-selectin水平明显升高,瑞舒伐他汀短期治疗能降低血清sE-selectin水平。

关键词: 慢性性心力衰竭, 瑞舒伐他汀, sE-selectin和sP-selectin

Abstract: AIM: To observe the effects of short-term treatment of rosuvastatin on soluble E-selectin (sE-selectin) and P -selectin (sP-selectin) in patients with congestive heart failure(CHF). METHODS: 70 patients with CHF were randomly divided into conventional treatment group and intervention group, the conventional treatment group received placebo and the intervention group received rosuvastain 10 mg /n for 4 weeks. The levels of sE-selectin and sP-selectin were measured before and after treatment by ELISA. RESULTS: The levels of sE-selectin and sP-selectin in serum of patients with heart function class Ⅳ were significantly higher than those in patients with heart function classⅡand Ⅲ(P<0.01),but there was no significant difference between classⅡand Ⅲ (P>0.05).The levels of sE-selectin and sP-selectin in two groups were significantly decreased after treatment (P<0.05 or P<0.01), compared with the conventional treatment group, only the sE-selectin level was significantly decreased (P<0.05). CONCLUSION: The levels of sE-selectin and sP-selectin are significantly increased along with heart function deterioration.The level of sE-selectin is decreased with short-term rosuvastatin treatment.

Key words: Chronic heart failure, Rosuvastatin, sE-selectin and sP-selectin

中图分类号:

R965.2

胡立群, 章琦, 陈莉, 李红旗, 尹长森. 瑞舒伐他汀对慢性心力衰竭患者血清中细胞因子浓度的影响[J]. 中国临床药理学与治疗学, 2010, 15(10): 1152-1155.

HU Li-qun, ZHANG Qi, CHEN Li, LI Hong-qi, YI Chang-sen. Effects of rosuvastatin on serum soluble cell adhesion molecule levels in patients with chronic heart failure[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(10): 1152-1155.

参考文献

[1] Leyva F,Anker SD,Godsland IF,et al.Uric acid in chronic heart failure:a marker of chronic inflammation[J]. Eur Heart J,1998,19(12):1746-1747.
[2] O'Connor CM, Gurbel PA, Serebruanny VL. Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure[J ]. Am J Cardiol, 1999, 83(9): 1345-1349.
[3] Sharma R,Coats AJ,Anker SD.The role of inflama matory mediators in chronic heart failure:cytokines,intric oxide,and endothelirr I[J].Int J Cardiol,2000,72(2):175-186.
[4] Valgimigli M,Curello S,Ceconi C,et al.Neurohormones,cytokines and programmed cell death in heart failure:a new paradigm for the remodeling heart[J]. Cardiovasc Drugs and Ther,2001,15(6):529-537.
[5] Kang PM, Lzumo S. Apoptosis and heard failure a cirtical review of the literature[J]. Cire Res,2000,86(11):1107-1113.
[6] Blankenberg S,Barbaux S, Tiret L. Adhesion molecules and atherosclerosis[J]. At herosclerosis, 2003, 170(2): 191-203.
[7] 倪红,储照虎,刘新亚.阿托伐他汀对鼠脑缺血再灌注后P选择素,人髓过氧化物的影响[J]. 中国临床药理学与治疗学,2009,14(12):1335-1337.
[8] 潘宜智,吾柏铭,洪小苏,等. 心力衰竭患者体内血小板活化状态的临床研究[J]. 中华心血管病杂志, 1996,24(3):214-215.
[9] 刘莉. 细胞黏附因子与慢性心力衰竭关系的相关研究进展[J].ITCM MAR, 2007,24(3):10-12.
[10] Node K,Fujita M,Kitakaze M,et al.Short-term statin therap improves cardiac function and symptoms in patients with idiopathic dilated cardiomy opathy [J]. Circulation, 2003,108(7):839-843.
[11] Sola S,Mirm Q,Lerakis S,et al.Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure[J]. J Am Coll Cardiol,2006,47(2):332-337.