超氧化物歧化酶同工酶异常表达与活性的临床前研究进展

摘要/Abstract

摘要： 超氧化物歧化酶同工酶(Cu,Zn-SOD、Mn-SOD和EC-SOD)在抗肿瘤和其它抗氧化损伤过程中表达和活性的变化较为复杂。在不同的病理生理条件下,超氧化物歧化酶同工酶的表达或活性在不同组织器官中会出现不同的状况,表达的数量和活性也各有特点。近几年,有关超氧化物歧化酶同工酶的异常表达及其活性的国内研究较少,本文对其进行归纳总结,以便为疾病诊断、治疗、预后和新药的研究开发以及抗氧化抗凋亡的研究提供参考。

关键词: 超氧化物歧化酶, 同工酶, 抗氧化, 抗凋亡

Abstract: The expression and activity of isoenzyme of superoxide dismutase (Cu, Zn-SOD, Mn-SOD and EC-SOD) are very complicated. The different pathogenesis or physiology could lead to the change of their expression and activity in the different tissues or organs. And the amount and activity of isoenzyme of superoxide dismutase changes correspondingly. The reports on the abnormal expression and activity of isoenzyme of superoxide dismutasethe were rarely seen in domestic researches. This paper reviewed the preclinical reports on the enzymes. It would provide evidences for the diagnosis and therapy of the disease, the research of new drugs and the research of anti-oxide and anti-apoptosis.

Key words: Superoxide dismutase, Isoenzyme, Anti-oxide, Anti-apoptosis

中图分类号:

R363.22

王占庆, 王金萍, 刘静. 超氧化物歧化酶同工酶异常表达与活性的临床前研究进展[J]. 中国临床药理学与治疗学, 2010, 15(10): 1195-1200.

WANG Zhan-qing, WANG Jin-ping, LIU Jing. Preclinical advances in the abnormal expression and its activity of isoenzyme of superoxide dismutase[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(10): 1195-1200.

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