血脂康抗心衰药效的临床研究及其降低血浆脑钠肽的相关性

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (11): 1284-1287.

血脂康抗心衰药效的临床研究及其降低血浆脑钠肽的相关性

廖祥明

北仑小港医院心内科,宁波 315801,浙江

收稿日期:2010-07-14 修回日期:2010-08-12 出版日期:2010-11-26 发布日期:2020-09-16
作者简介:廖祥明,男,副主任医师,主要从事心内科工作。Tel: 13586830406 E-mail: jickentmloo@163.com

Cardiac protection effect of Xuezhikang on patients with chronic heart failure correlates positively to lowering plasma brain natriuretic peptide levels

LIAO Xiang-ming

Beilun Xiaogang Hospital, Department of Cardiology, Ningbo 315800, Zhejiang, China

Received:2010-07-14 Revised:2010-08-12 Online:2010-11-26 Published:2020-09-16

摘要/Abstract

摘要： 目的: 观察血脂康对慢性心力衰竭患者心功能、血浆脑钠肽和高敏C反应蛋白水平的影响,评价该药抗心衰疗效,初步探讨其作用机制。方法: 80例慢性心力衰竭患者随机分为观察组和对照组,常规抗心衰治疗,观察组加服血脂康,疗程8周。治疗前后用彩超测定左心室射血分数 (LVEF)和左心室舒张末期内径 (LVDd),以ELISA法与散射比浊法分别测定血浆N-末端脑钠肽前体 (NT-proBNP)和高敏C反应蛋白 (HS-CRP) 水平。结果: 治疗后观察组总有效率明显高于对照组, LVEF明显升高、LVDd明显下降,血浆NT-proBNP、HS-CRP水平均明显下降;观察组血浆NT-proBNP与LVEF呈负相关 (r=-0.72,P<0.05),与LVDd呈正相关 (r=0.75, P<0.05);血浆HS-CRP水平与LVDd呈正相关 (r=0.31, P<0.05),与LVEF增加呈负相关 (r=-0.387, P<0.05)。结论: 血脂康能降低血浆NT-proBNP、HS-CRP水平,抑制左心室重构,改善心脏功能,在慢性心力衰竭防治中起重要作用;其作用机制可能与改善神经体液功能有关。

关键词: 慢性心力衰竭, N-末端脑钠肽前体, 高敏C反应蛋白, 血脂康

Abstract: AIM: To observe the cardiac protection effect of Xuezhikang on cardiac function in patients with chronic heart failure (CHF) and its relation with plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity high-sensitivity C-reactive protein (HS-CRP) levels. METHODS: 80 patients with CHF were randomly divided into two groups;the control group received routine anti-failure treatment, and the observation group received routine anti-failure treatment in combination with Xuezhikang for 8 weeks. The cardiac function, i.e., left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDd) , were measured before and after treatment with color Doppler ultrasound; plasma NT-proBNP, HS-CRP levels were determined by ELISA method and nephelometry respectively. RESULTS: The cardiac function improved more effectively in the observation group than that in the control group. The LVEF increasing and LVDd decreasing were correlated to plasma NT-proBNP levels (r=-0.72 and 0.75, P<0.05 respectively ) and HS-CRP levels (r=-0.387 and 0.31, P<0.05). CONCLUSION: Xuezhikang is effective in anti-failure treatment. Reducing plasma NT-proBNP and HS-CRP levels may be the possible mechanism of the drug, but NT-proBNP reducing is more important.

Key words: Chronic heart failure, N-terminal pro-brain natriuretic peptide, High-sensitivity C-reactive protein, Xuezhikang

中图分类号:

R541
R969.4

廖祥明. 血脂康抗心衰药效的临床研究及其降低血浆脑钠肽的相关性[J]. 中国临床药理学与治疗学, 2010, 15(11): 1284-1287.

LIAO Xiang-ming. Cardiac protection effect of Xuezhikang on patients with chronic heart failure correlates positively to lowering plasma brain natriuretic peptide levels[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(11): 1284-1287.

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