氯吡格雷抵抗的基因多态性探讨

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (11): 1288-1293.

氯吡格雷抵抗的基因多态性探讨

贺春晖^1,2, 胡琴², 邹建军¹, 陈绍良³, 樊宏伟¹, 谢红光¹, 朱余兵¹

¹南京医科大学附属南京第一医院国家药物临床药理实验室,南京 210006,江苏;
²南京医科大学药学院,南京 210029,江苏;
³南京医科大学附属南京第一医院心内科,南京 210006,江苏

收稿日期:2010-09-06 修回日期:2010-11-05 出版日期:2010-11-26 发布日期:2020-09-16
通讯作者: 邹建军,男,博士,主管药师,主要从事基因多态性和临床个体化给药研究。Tel: 13814186761 E-mail: zoujianjun100@126.com
作者简介:贺春晖,女,硕士研究生,研究方向:药物分析学和临床药学。Tel: 13062588549 E-mail: hechunhui1986@yahoo.com.cn
基金资助:
国家自然科学基金资助项目(30901830)

Study on genetic factors of clopidogrel resistance

HE Chun-hui^1,2, HU Qin² , ZOU Jian-jun¹, CHEN Shao-liang³, FAN Hong-wei¹, XIE Hong-guang¹, ZHU Yu-bing¹

¹Department of Clinical Pharmacology, Nanjing First Hospital of Nanjing Medical University, Nanjing 210006, Jiangsu, China;
²College of Pharmacy, Nanjing Medical University, Nanjing 210006, Jiangsu, China;
³Department of Cardiology, Nanjing First Hospital of Nanjing Medical University, Nanjing 210006, Jiangsu, China

Received:2010-09-06 Revised:2010-11-05 Online:2010-11-26 Published:2020-09-16

摘要/Abstract

摘要： 氯吡格雷作为抗血小板药物,是冠心病患者经皮冠状动脉介入术后预防血栓事件的标准治疗药物之一。然而由于个体对氯吡格雷抗血小板作用的反应性存在差异,部分患者在服用常规剂量氯吡格雷后存在抵抗现象而发生临床血栓事件。目前氯吡格雷抵抗的机制尚不十分清楚,基因多态性被认为是其中一个重要的原因。本文就转运体、药物代谢酶和受体基因多态性对氯吡格雷药动学、药效学和临床事件的影响作一探讨。

关键词: 氯吡格雷抵抗, 基因多态性, 细胞色素P450

Abstract: Clopidogrel is an antiplatelet drug, which has been confirmed as one of the standard treatments for the prevention of stent thrombosis in coronary heart disease(CHD). However, ischemic events still occur in population under routine dosage of clopidogrel treatment, which may due to the variabilities of platelet response to clopidogrel. This phenomenon is defined as clopidogrel resistance(CR). The mechanism of CR has not been clearly elucidated yet, gene polymorphism is considered as one of the most important reasons. In this review, we will discuss the impact of genetic variations of transportors, drug metabolizing enzymes and receptors in pharmacokinetic, pharmacodynamic and clinical responses to clopidogrel.

Key words: Clopidogrel resistance, Gene polymorphism, Cytochrome P450

中图分类号:

R969

贺春晖, 胡琴, 邹建军, 陈绍良, 樊宏伟, 谢红光, 朱余兵. 氯吡格雷抵抗的基因多态性探讨[J]. 中国临床药理学与治疗学, 2010, 15(11): 1288-1293.

HE Chun-hui, HU Qin , ZOU Jian-jun, CHEN Shao-liang, FAN Hong-wei, XIE Hong-guang, ZHU Yu-bing. Study on genetic factors of clopidogrel resistance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(11): 1288-1293.

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