中性粒细胞明胶酶相关脂质运载蛋白:早期诊断成人心脏术后急性肾损伤的生物学指标

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (11): 1305-1309.

中性粒细胞明胶酶相关脂质运载蛋白:早期诊断成人心脏术后急性肾损伤的生物学指标

张近波¹, 张小乐², 许国斌¹, 董志兵³, 李传光⁴, 王文龙⁵

¹温州医学院附属温岭医院EICU,温岭 317500,浙江;
²河北省滦南县医院血液透析中心,滦南 063500,河北;
³温州医学院附属温岭医院心内科, ⁴微创中心, ⁵肾内科,温岭 317500, 浙江

收稿日期:2010-03-14 修回日期:2010-07-12 出版日期:2010-11-26 发布日期:2020-09-16

Neutrophil gelatinase-associated lipocalin: a novel biomarker for the early diagnosis of acute kidney injury following adult cardiothoracic surgery

ZHANG Jin-bo¹, ZHANG Xiao-le², XU Guo-bin¹, DONG Zhi-bing³, LI Chuan-guang⁴, WANG Wen-long⁵

¹Department of EICU, Wenling Hospital Affiliated to Wenzhou Medical College, Wenling 317500,Zhejiang,China;
²Hebei Luan nan Hospital, Luannan 063500, Hebei, China;
³Department of Cardiology, Wenling Hospital Affiliated to Wenzhou Medical College, ⁴ Centre of Microtrauma, ⁵ Department of Nephrology, Wenling 317500,Zhejiang,China

Received:2010-03-14 Revised:2010-07-12 Online:2010-11-26 Published:2020-09-16
About author:ZHANG Jin-bo, corresponding author.Tel: 15988967231 E-mail: zhangjinbo0661@163.com

摘要/Abstract

摘要： 心脏术后急性肾损伤的出现会增加患者的死亡率,需要寻找早期诊断急性肾损伤的生物学指标。中性粒细胞明胶酶相关脂质运载蛋白似乎是早期诊断急性肾损伤的生物学指标,它是否能够早期诊断急性肾损伤已经做了广泛的报道。本文综述了已有研究证明它是否能够早期诊断急性肾损伤。

关键词: 急性肾损伤, 中性粒细胞明胶酶相关脂质运载蛋白, 生物学指标, 心脏手术

Abstract: It is needed to develop early biomarkers of acute kidney injury following cardiac surgery, whose morbidity and mortality are increased by its presence. NGAL(neutrophil gelatinase-associated lipocalin) seems to be a promising biomarker for the early diagnosis of acute kidney injury (AKI). However, a wide range in its predictive value has been reported. It is reviewed whether NGAL can early diagnosis AKI actually.

Key words: Acute kidney injury, Neutrophil gelatinase-associated lipocalin, Biomarker, Cardiothoracic surgery

中图分类号:

R692

张近波, 张小乐, 许国斌, 董志兵, 李传光, 王文龙. 中性粒细胞明胶酶相关脂质运载蛋白:早期诊断成人心脏术后急性肾损伤的生物学指标[J]. 中国临床药理学与治疗学, 2010, 15(11): 1305-1309.

ZHANG Jin-bo, ZHANG Xiao-le, XU Guo-bin, DONG Zhi-bing, LI Chuan-guang, WANG Wen-long. Neutrophil gelatinase-associated lipocalin: a novel biomarker for the early diagnosis of acute kidney injury following adult cardiothoracic surgery[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(11): 1305-1309.

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