多巴胺D2受体调控睡眠-觉醒研究进展

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (4): 361-366.

• 专论 • 下一篇

多巴胺D₂受体调控睡眠-觉醒研究进展

许奇¹, 曲卫敏², 黄志力^1,2

复旦大学¹医学神经生物学国家重点实验室, ²上海医学院药理学系,上海 200032

收稿日期:2010-04-05 修回日期:2010-04-15 发布日期:2020-09-17
作者简介:许奇,男,博士研究生,研究方向:睡眠与失眠机制。E-mail: ahmuxq@yahoo.com.cn;黄志力,男,博士,教授,博士生导师,研究方向:睡眠与失眠机制。E-mail: huangzl@fudan.edu.cn
基金资助:
国家自然科学基金(30625021,30821002,30970955);国家“重大新药创制”科技重大专项 (2009ZX09303-006);上海市科委基金（09PJ1401800,09JC1402500,10XD1400400);上海市重点学科建设项目(B119)

Progress in sleep-wake regulation of dopamine D₂ receptor

XU Qi¹, QU Wei-min², HUANG Zhi-li^1,2

¹State Key Laboratory of Medical Neurobiology, ²Department of Pharmacology, Shanghai Medical College of Fudan University, Shanghai 200032, China

Received:2010-04-05 Revised:2010-04-15 Published:2020-09-17

摘要/Abstract

摘要： 脑内多巴胺(dopamine,DA)参与觉醒相关的运动、认知和奖赏等行为调控。DA能神经元主要位于黑质致密部和腹侧被盖区。DA受体(receptor,R)包括:D₁R、D₂R(D_<sub>2S和D_2L)、D₃R、D₄R和D₅R五种亚型。中枢神经内D₁R和D₂R数目占绝对优势,D₂R对内源性DA的亲和力显著高于D₁R。近年来,药理学和基因剔除动物等研究发现:D₂R是维持觉醒的重要受体,本文综述其研究进展。

关键词: 多巴胺, D₂受体, 睡眠, 觉醒, 基因剔除小鼠

Abstract: Dopamine (DA) modulates diverse wake-related behaviors including movement, reward, and cognition. Dopaminergic neurons are located in the substantia nigra pars compacta and ventral tegmental area. There are five distinct DA receptors (R): D₁R, D₂R (D_2SR and D_2LR), D₃R, D₄R and D₅R in the central nervous system, in which D₁R and D₂R are majorly expressed. The affinity of D₂R for endogenous DA is significantly higher than that of D₁R. Recently, studies by pharmacological and gene knock-out animals revealed that dopamine D₂R is essential inmaintaining wakefulness. Here, we review the progress on roles of D₂R in sleep-wake regulation.

Key words: Dopamine, D₂ receptor, Knockout mice, Sleep, Wake

中图分类号:

许奇, 曲卫敏, 黄志力. 多巴胺D₂受体调控睡眠-觉醒研究进展[J]. 中国临床药理学与治疗学, 2010, 15(4): 361-366.

XU Qi, QU Wei-min, HUANG Zhi-li. Progress in sleep-wake regulation of dopamine D₂ receptor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(4): 361-366.

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多巴胺D₂受体调控睡眠-觉醒研究进展

Progress in sleep-wake regulation of dopamine D₂ receptor

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