Keap1在氧化应激方面的研究进展

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (5): 596-600.

• 综述与讲座 • 上一篇

Keap1在氧化应激方面的研究进展

刘芳¹, 杜志银², 王应雄³

¹重庆市江北区第一人民医院检验科,重庆 400020;
²重庆医科大学信息管理系,重庆 400016;
³重庆医科大学基础医学院,重庆 400016

收稿日期:2010-02-20 修回日期:2010-04-01 出版日期:2010-05-26 发布日期:2020-09-16
通讯作者: 王应雄,男,教授,博士生导师,研究方向:分子遗传与临床检验诊断。Tel: 023-68485001 E-mail: wyx61221@yahoo.com.cn
作者简介:刘芳,女,博士,研究方向:分子遗传与临床检验诊断。Tel: 023-67874982 E-mail: liufangshuo@126.com

Progress in study on relationship of Keap1 with oxidative stress

LIU Fang¹, DU Zhi-ying², WANG Ying-xiong³

¹First People's Hospital in Jiangbei District in Chongqing, Chongqing 400020, China;
²Faculty of Information Management, Chongqing University of Medical Science, Chongqing 400016, China;
³College of Bosis Medical Scinece, Chongqing University of Medical Science, Chongqing 400016, China

Received:2010-02-20 Revised:2010-04-01 Online:2010-05-26 Published:2020-09-16

摘要/Abstract

摘要： 外界环境的刺激会破坏生物体内的氧化还原平衡,产生氧化应激。为了应对氧化应激产生的毒性作用,体内细胞在进化过程中产生了复杂的机制来应对氧化应激,Keap1(Kelch-like Ech-associated protein-1)是抗氧化应答机制中最重要的分子之一。本文从Keap1的克隆和表达、定位及结构以及功能方面对Keap1在生物体内应对氧化应激所起的作用进行了综述。

关键词: Keap1, 氧化应激, Nrf2

Abstract: Exogenous chemical insults can cause severe damage to the redox homeostasis of biomolecules and lead to oxidative stress reaction. In order to consult these toxicant reaction, eukaryotic cells have evolved complex defense mechanisms to cope with toxicant-induced oxidative stress. One of the most important cellular defense mechanisms against oxidative stress is mediated by the transcription factor Nrf2 and its parter Keap1. This article reviewed the clone, expression, location, structure and function of Keap1 and highlight the importance of Keap1 as a molecular target for disease prevention.

Key words: Keap1, Oxidative stress, Nrf2

中图分类号:

R994

刘芳, 杜志银, 王应雄. Keap1在氧化应激方面的研究进展[J]. 中国临床药理学与治疗学, 2010, 15(5): 596-600.

LIU Fang, DU Zhi-ying, WANG Ying-xiong. Progress in study on relationship of Keap1 with oxidative stress[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(5): 596-600.

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Keap1在氧化应激方面的研究进展

Progress in study on relationship of Keap1 with oxidative stress

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