遗传药理学与高血压药物治疗进展

摘要/Abstract

摘要： 遗传药理学对于解释药物反应的个体差异并进行个体化用药具有重要意义。近年来其新技术在高血压治疗等方面的临床应用引起了广泛关注。本文结合本临床评价中心实践经验,从药代动力学和药效动力学方面对与高血压治疗相关的基因多态性研究进展,及其对高血压个体化治疗的影响进行综述。可以认为基因芯片技术等药物基因组学的新发展,必将对高血压等疾病的个体化治疗发挥更显著的促进作用。

关键词: 药物基因组学, 遗传药理学, 药代动力学, 药效动力学, 高血压, 基因芯片

Abstract: Pharmacogenetics is essential for explanation on individual variation of drug responses, and application of personalized medicine. Recently new technological developments draw attentions for their clinical applications in hypertension therapy. This article aims to review the advancements in gene polymorphisms related with hypertension therapy from pharmacokinetics and pharmacodynamics points, as well as their impacts on hypertension therapy, according to ourexperiences in such fields. We conclude that pharmacogenomics advancements such as gene-array would greatly improve personalized medicine of hypertension and other diseases in the future.

Key words: Pharmacogenomics, Pharmacogenetics, Pharmacokinetics, Pharmacodynamics, Hypertension, Gene-array

中图分类号:

R968

沈杰, 谢海棠, 刘昭前. 遗传药理学与高血压药物治疗进展[J]. 中国临床药理学与治疗学, 2010, 15(6): 705-714.

SHEN Jie, XIE Hai-tang, LIU Zhao-qian. Adrancement in pharmacogentics and hypenteasion medicine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(6): 705-714.

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