丙泊酚的作用机制及临床新应用

摘要/Abstract

摘要： 作为一种静脉全麻药,丙泊酚因起效迅速、作用时间短、清醒快而完全、副作用少等优点自上世纪80年代进入临床以来应用广泛。但近年研究发现,除了麻醉作用外,丙泊酚还有许多其他非麻醉效应。丙泊酚具有减少脑缺血时神经元的损伤,保护缺血器官,抑制血小板聚集,减少术后呕吐,免疫调节,止痛等效应。这些麻醉外效应将来可能进一步扩大丙泊酚的临床应用范围。本文对近年来对丙泊酚的药理学研究机制及新的临床应用进行综述。

关键词: 丙泊酚, 麻醉作用, 神经保护, 免疫调节

Abstract: Propofol is a short-acting intravenous anaesthetic agent which has the advantages of minimal side effects, controllable anaesthetic state, quick onset and rapid emergence from general anaesthesia.Apart from these anaesthetic advantages, it also has some non-anaesthetic effects. It has been found that propofol can protect heart, kidney and liver from ischemia-reperfusion injury. It has neuro-protective effects, immunomodulatory activity, antiemetic effects, antinociceptive actions and amnesic effects. It is obvious that these nonanaesthetic effects that propofol exerts can substantially change the daily use of propofol and may expand its pharmacological and clinical use. Advances in pharmacological mechanism and new clinical of propofol in recent years were summarized in this paper.

Key words: Propofol, Anaesthetic effects, Neuro-protection, Immunomodulation

中图分类号:

刘强, 洪江, 李晓宇. 丙泊酚的作用机制及临床新应用[J]. 中国临床药理学与治疗学, 2010, 15(7): 836-840.

LIU Qiang, HONG Jiang, LI Xiao-yu. Pharmacological mechanism of propofol and its new clinical usage[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(7): 836-840.

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