植物甾醇对非细菌性前列腺炎治疗作用的实验研究

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (9): 991-996.

植物甾醇对非细菌性前列腺炎治疗作用的实验研究

程丽艳, 郑晓亮, 屠凌岚, 史红

浙江省医学科学院药物所,杭州 310013,浙江

收稿日期:2010-07-29 修回日期:2010-09-10 出版日期:2010-09-26 发布日期:2020-09-17
通讯作者: 史红,女,研究员,硕士生导师,从事中药药理学研究及新药开发。Tel: 0571-88215621, E-mail: shihong86@yahoo.com.cn
作者简介:程丽艳,女,硕士,助理研究员,从事中药药理学研究。Tel: 0571-88215621, E-mail: ziding6374@163.com
基金资助:
国家中医药管理局中医药科学技术研究专项(06-07ZP23)资助

Protective effects of Phytosterols on abacterial prostatitis

CHENG Li-yan, ZHENG Xiao-liang, TU Ling-lan, SHI Hong

Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China

Received:2010-07-29 Revised:2010-09-10 Online:2010-09-26 Published:2020-09-17

摘要/Abstract

摘要： 目的: 观察植物甾醇对非细菌性前列腺炎的保护作用。方法: 采用角叉菜胶诱导急性前列腺炎模型、消痔灵诱导慢性前列腺炎模型:取前列腺液镜下观察卵磷脂小体和白细胞数并计算前列腺指数,观察植物甾醇对急慢性非细菌性前列腺炎的抑制作用;采用巴豆油致耳肿胀模型、光刺激致痛模型及棉球肉芽肿模型观察植物甾醇的抗炎镇痛作用;采用水负荷试验观察植物甾醇对大鼠的利尿作用。结果: 植物甾醇 150 mg/kg 能明显降低急性前列腺炎模型前列腺液中的白细胞数,增加卵磷脂小体密度。植物甾醇 150 mg/kg 能明显降低慢性前列腺炎模型前列腺液中的白细胞数,增加卵磷脂小体密度,同时各剂量组均能不同程度改善前列腺组织的病理变化。植物甾醇 150 mg/kg 对耳肿胀试验,肉芽肿试验及光刺激致痛试验具有良好的抑制作用;各剂量组植物甾醇均能明显增加水负荷大鼠不同时间段的尿量。结论: 植物甾醇对实验性非细菌性前列腺炎有明显的抑制作用,并具有利尿作用。

关键词: 植物甾醇, 非细菌性前列腺炎

Abstract: AIM: To investigate the protective effects of Phytosterols on abacterial prostatitis in rats.METHODS: Experimental abacterial prostatitis induced by xiaozhiling and carrageenan respectively were used to observe the protective effects of Phytosterols. Auricle swelling induced by croton oil, granuloma induced by cotton ball and pain induced by photothermal stimulation in mice were used to detect the anti-inflammatory and analgesic effects of Phytosterols. Water-loaded rats were used to detect the diuresis effect of Phytosterols.RESULTS: In xiaozhiling-induced chronic abacterial prostatitis rats treated with 150 mg/kg of Phytosterols, the number of white blood cells in prostatic secretion was obviously decreased, and the density of lecithin corpuscle in prostatic secretion was obviously increased, and the edema, inflammatory infiltration and proliferation in prostate were partly recovered, as well as in carrageenan-induced acute abacterial prostatitis rats. The acute auricular swelling induced by croton oil, late proliferative granuloma induced by cotton ball and pain induced by photothermal stimulation in mice were attenuated by 150 mg/kg of Phytosterols. The urinary amount was significantly increased by 150 mg/kg of Phytosterols in water-loaded rats in 4 hours.CONCLUSION: These results demonstrate that Phytosterols have good protective effects on abacterial prostatitis.

Key words: Phytosterols, Abacterial prostatitis

中图分类号:

R965.2

程丽艳, 郑晓亮, 屠凌岚, 史红. 植物甾醇对非细菌性前列腺炎治疗作用的实验研究[J]. 中国临床药理学与治疗学, 2010, 15(9): 991-996.

CHENG Li-yan, ZHENG Xiao-liang, TU Ling-lan, SHI Hong. Protective effects of Phytosterols on abacterial prostatitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(9): 991-996.

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