CYP2D6基因多态性及对药物代谢的影响

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (1): 105-110.

CYP2D6基因多态性及对药物代谢的影响

韩璐, 刘洁

中南大学临床药理研究所,长沙 410078,湖南

收稿日期:2010-11-01 修回日期:2010-12-25 发布日期:2020-09-16
通讯作者: 刘洁,女,博士,副教授,硕士研究生导师,研究方向:临床药理学、遗传药理学。Tel: 0731-84805380 E-mail: liujiezhj@126.com
作者简介:韩璐,女,硕士研究生,研究方向:临床药理学、遗传药理学。Tel: 0731-84805380 E-mail: junnyhan@163.com
基金资助:
国家自然科学基金项目(30600774及81070902);教育部“新世纪优秀人才支持计划”(NCET-08-0567);2010年中南大学硕士生学位论文创新资助项目资助

Polymorphism of CYP2D6 and the influence to the drug metabolism

HAN Lu, LIU Jie

Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China

Received:2010-11-01 Revised:2010-12-25 Published:2020-09-16

摘要/Abstract

摘要： CYP2D6代谢酶是细胞色素P450家族中的成员之一,是参与Ⅰ相代谢和众多内源性物质和不同药物消除的酶。虽然它在肝脏中的含量大约只占肝脏总量的2%,但在临床上却参与了25%以上的常用药物的代谢活动。在所有参与药物代谢的细胞色素P450基因家族中,CYP2D6是唯一不能被诱导的酶,这种酶具有广泛的多态性,这种多态性对酶的药物代谢功能具有重要影响,CYP2D6的这种多态性和药物代谢功能所表现的对个体活性的差异,在遗传药理学上具有重要意义。本文从CYP2D6基因多态性和它对药物代谢的影响这两方面进行了阐述。

关键词: CYP2D6, 基因多态性, 药物代谢

Abstract: CYP2D6 is a member of cytochrome P450 gene family - a group of enzymes that is responsible for phase I metabolism and elimination of numerous endogenous substrates and a diverse array of drugs. It is now thought to be involved in the metabolism of up to 25% of the drugs that are in common use in the clinic, despite its low hepatic content (about 2 %). Among the drug-metabolizing cytochrome P450s, CYP2D6 is the only non-inducible enzyme and is highly polymorphic, which results in a large contribution of genetic variation to its inter-individual variation in enzyme activity and is an enzyme of great historical importance for pharmacogenetics. Here we summarize the polymorphism of CYP2D6 gene and their influence to drug metabolism.

Key words: CYP2D6, Genetic polymorphism, Drug metabolism , , , ,

中图分类号:

R969

韩璐, 刘洁. CYP2D6基因多态性及对药物代谢的影响[J]. 中国临床药理学与治疗学, 2011, 16(1): 105-110.

HAN Lu, LIU Jie. Polymorphism of CYP2D6 and the influence to the drug metabolism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(1): 105-110.

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