延红胶囊治疗跌打损伤的药效学实验研究

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (10): 1101-1104.

延红胶囊治疗跌打损伤的药效学实验研究

张丹丹, 张俊威, 张强, 蒙艳丽, 王伟明

黑龙江省中医研究院,哈尔滨 150036,黑龙江

收稿日期:2011-08-12 修回日期:2011-09-26 出版日期:2011-10-26 发布日期:2011-11-02
通讯作者: 王伟明,女,博士,研究员,硕士生导师,主要从事中药新药的研究。Tel: 0451-55665478, E-mail: zyyjy@163.com
作者简介:张丹丹,女,硕士,实习研究员,研究方向:中药药理学。Tel: 13633602539, E-mail: zhangdandan1616@163.com

An pharmacodynamic study of Yanhong capsule on injuries from impacts

ZHANG Dan-dan, ZHANG Jun-wei, ZHANG Qiang, MENG Yan-li, WANG Wei-ming

Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150036, Heilongjiang, China

Received:2011-08-12 Revised:2011-09-26 Online:2011-10-26 Published:2011-11-02

摘要/Abstract

摘要： 目的: 观察延红胶囊治疗大鼠跌打损伤的疗效。方法: 击打致大鼠局部血瘀实验观察病理组织学变化;检测血瘀大鼠血流变学指标;二甲苯致小鼠耳肿胀实验观察耳肿胀率变化;醋酸所致小鼠扭体实验观察对扭体次数的影响。结果: 延红胶囊能改善击打致大鼠局部血瘀的体表淤血和水肿症状(P＜0.05);能恢复大鼠肌纤维损伤,减少间质水肿;能显著降低血瘀模型大鼠的高、中、低切变率全血黏度、血浆黏度(P<0.05),对血流变学指标有显著的改善作用;能降低二甲苯致小鼠的耳肿胀率(P＜0.05);能减少醋酸致小鼠的扭体次数(P＜0.05)。结论: 延红胶囊具有一定的行气活血散瘀、抗炎、止痛作用。

关键词: 延红胶囊, 跌打损伤, 活血化瘀, 药效学研究

Abstract: AIM: To investigate the effects of Yanhong capsule on injury rats. METHODS: The changes of pathohistology were observed by local blood stasis on rats induced by hitting. The levels of blood rheology were detected. The rates of ear swelling induced by xylene were observed. The times of writhing induced by acetic acid were observed. RESULTS: Yanhong capsule could improve the symptoms of the surface congestion and edema on local blood stasis rats induced by hitting, recover the damage of muscle fiber, and reduce edema of the interstitial(P<0.05). Yanhong capsule could significantly reduce plasma viscosity, whole blood viscosity of high, medium, low shear rate(P<0.05), and significant improve indexes on blood rheological property. Yanhong capsule could reduce the rates of ear edema induced by xylene (P<0.05), and reduce the times of the writhing induced by acetic acid (P<0.05). CONCLUSION: Yanhong capsule has a great action on promotion blood circulation to dissipate, anti-inflammatory and painkillers.

Key words: Yanhong capsule, Injuries from impacts, Promotion blood circulation to dissipate, Pharmacodynamic study

中图分类号:

R965.2

张丹丹, 张俊威, 张强, 蒙艳丽, 王伟明. 延红胶囊治疗跌打损伤的药效学实验研究[J]. 中国临床药理学与治疗学, 2011, 16(10): 1101-1104.

ZHANG Dan-dan, ZHANG Jun-wei, ZHANG Qiang, MENG Yan-li, WANG Wei-ming. An pharmacodynamic study of Yanhong capsule on injuries from impacts[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(10): 1101-1104.