牛磺酸对果糖诱导高血压大鼠的降压作用及其机制的研究

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (2): 160-164.

牛磺酸对果糖诱导高血压大鼠的降压作用及其机制的研究

米清仙¹, 张明升²

¹太原市妇幼保健院,太原 030001,山西;
²山西医科大学药理教研室,太原 032200,山西

收稿日期:2010-11-10 修回日期:2010-12-08 发布日期:2011-04-20
通讯作者: 张明升,男,博士,教授,博士生导师,研究方向:心血管药理学。Tel: 0351-4135079 E-mail: 4156589@sina.com
作者简介:米清仙,女,硕士研究生,研究方向:心血管药理学。Tel: 0351-4135079 E-mail: 971498758@qq.com

Hypotensive effect and its mechanism of taurine in fructose-induced hypertension rats

MI Qing-xian¹, ZHANG Ming-sheng²

¹Taiyuan City Maternal and Child Health Hospital, Taiyuan 030001, Shanxi, China;
²Department of Pharmacology, Shanxi Medical University, Taiyuan 030001, Shanxi, China

Received:2010-11-10 Revised:2010-12-08 Published:2011-04-20

摘要/Abstract

摘要： 目的:探讨牛磺酸对果糖诱导的胰岛素抵抗合并高血压大鼠的降压作用及其机制。方法: 大鼠被随机分为对照组、果糖组和牛磺酸组。果糖组和牛磺酸组以高果糖饲料喂养5周,对照组以相同热量的普通饲料喂养,牛磺酸组加入2%的牛磺酸,3组动物自由饮用白开水。尾套法测定3组动物的收缩期血压,同时测定空腹血糖、甘油三酯和空腹血胰岛素。颈动脉插管法观察3组动物麻醉状态下心功能参数对静脉注射去甲肾上腺素的反应。用离体血管环法观察大鼠胸主动脉对去甲肾上腺素、乙酰胆碱和酸化亚硝酸钠的反应。结果: 果糖组大鼠收缩压,空腹血糖、血甘油三酯和空腹血胰岛素明显高于对照组和牛磺酸组。牛磺酸组大鼠对去甲肾上腺素引起的血压和心率变化幅度明显小于果糖组。果糖组对乙酰胆碱的舒张作用明显弱于对照组和牛磺酸组。结论:牛磺酸对果糖诱导的胰岛素抵抗合并的高血压有降压作用,其机制可能是通过保护血管内皮功能和改善心血管压力反射敏感性实现的。

关键词: 牛磺酸, 果糖, 胰岛素抵抗, 血压

Abstract: AIM: To investigate the hypotensive effect and its mechanism of taurine in the fructose-induced insulin resistance and hypertension rats.METHODS: The rats were divided into three groups. The rats in the control group were fed with standard rat chow and had free access to distilled water, while the rats in the fructose group had free access to a high-fructose diet, and the rats in the taurine group had free access to a diet containing high-fructose and received a 2% taurine solution as drinking water. Systolic blood pressure, insulin, triglycerides and glucose were measured. The variations of heart function parameters to noradrenaline with arterial cannulation in anaesthetic rats were observed and the reactivity of isolated thoracic aortic rings to noradrenaline, acetylcholine and acidified to NaNO were explored.RESULTS:The systolic blood pressure, serum level of insulin, triglycerides and glucose in fructose group were apparently higher than those in control and taurine groups. The vagectomy-induced variations of blood pressure and heart rate in control and taurine groups were smaller than those in fructose group rats. The sensitivity to acetylcholine in fructose group was weaker than that in control and taurine groups.CONCLUSION: Taurine ameliorates the metabolic disorder induced by fructose, and decreases the blood pressure by protecting endothelium and improving baroreflex sensitivity.

Key words: Taurine, Fructose, Insulin resistance, Blood pressure

中图分类号:

R965.1

米清仙, 张明升. 牛磺酸对果糖诱导高血压大鼠的降压作用及其机制的研究[J]. 中国临床药理学与治疗学, 2011, 16(2): 160-164.

MI Qing-xian, ZHANG Ming-sheng. Hypotensive effect and its mechanism of taurine in fructose-induced hypertension rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 160-164.

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