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中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (3): 322-324.

• 药物治疗学 • 上一篇    下一篇

苯扎溴铵溶液防治皮肤创伤愈合瘢痕的临床观察

顾家富, 晋继忠   

  1. 河南省郸城县第二人民医院,郸城 477150,河南
  • 收稿日期:2011-02-24 修回日期:2011-03-12 出版日期:2011-03-26 发布日期:2011-05-18
  • 作者简介:顾家富,男,本科,副主任药师,研究方向:临床药学。Tel: 0394-3208895 E-mail: gujiafu629599@163.com

Clinical observation on benzalkonium bromide solution preventing skin wound healing and scar treatment

GU Jia-fu, JIN Ji-zhong   

  1. Dancheng Second People's Hospital of Henan Province, Dancheng 477150 ,Henan, China
  • Received:2011-02-24 Revised:2011-03-12 Online:2011-03-26 Published:2011-05-18

摘要: 目的: 观察 0.1%苯扎溴铵溶液对皮肤创伤愈合瘢痕的防治疗效。方法: 将974例创伤患者随机分为治疗组及对照组各487例,用 0.5%的络合碘溶液消毒皮肤,治疗组用3%过氧化氢溶液、0.9%氯化钠注射液、0.1%苯扎溴铵溶液依次清创伤口,缝合后用 0.1%苯扎溴铵溶液湿敷包扎伤口,每 2 d 一次,至伤口愈合,对照组用3%过氧化氢溶液和 0.9%氯化钠注射液清创伤口,缝合后常规包扎,观察两组远期皮肤愈合瘢痕的形成。结果: 皮肤创伤愈合12月后两组的温哥华瘢痕量表评分差异显著,治疗组低于对照组的评分。结论: 0.1%苯扎溴铵溶液对皮肤创伤愈合后的瘢痕形成有防治疗效。

关键词: 苯扎溴铵, 皮肤, 愈合瘢痕

Abstract: AIM: To observe 0.1% benzalkonium bromide solution on the prevention and treatment of skin wound healing and scar treatment.METHODS: 974 cases of trauma were randomly divided into treatment group and control group each for 487 cases. 0.5% of the complex with iodine solution was used for skin disinfection. 3% hydrogen peroxide solution, 0.9% sodium chloride injection, 0.1% benzalkonium bromide solution were continuously used to clean the wound. The 0.1% benzalkonium bromide solution was wet compressed after suture with bandage wounds, once every 2 days to wound healing in treatment group. 3% hydrogen peroxide solution and 0.9% sodium chloride injection were used to clear the wound in the control group, then bandage usually.The long-term healing scar of two groups were observed.RESULTS: The Vancouver scar scale of two groups had significantly difference in 12 months after skin wound healing, the treatment group was lower.CONCLUSION: 0.1% benzalkonium bromide solution has preventive effect on the skin and scar formation after wound healing.

Key words: Benzalkonium bromide , Skin, Healing scar

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