间充质干细胞源性外泌体及其在创面修复中的研究进展

doi:10.12092/j.issn.1009-2501.2019.07.017

中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (7): 826-832.doi: 10.12092/j.issn.1009-2501.2019.07.017

间充质干细胞源性外泌体及其在创面修复中的研究进展

刘青武1,2，陈佳1,2，蒙玉娇1,2，冯放2，郭昕炜1，郭简宁1,2，张金超1，林燕1，何秀娟1，李萍1,2

¹ 首都医科大学附属北京中医医院北京市中医研究所，北京 100010；²北京中医药大学，北京 100029

收稿日期:2019-03-18 修回日期:2019-05-30 出版日期:2019-07-26 发布日期:2019-07-29
通讯作者: 何秀娟，女，副研究员，主要从事中医疮疡外科研究。 E-mail: hexiujuan75@sina.com 李萍，女，博士生导师，主要从事中医皮外科研究工作。 E-mail: liping411@126.com
作者简介:刘青武，男，在读博士研究生，主要从事皮肤外科研究工作。 Tel: 18811016462 E-mail: 454293138@qq.com
基金资助:
国家自然科学基金项目（81774328，81774312，81804093）；北京市自然科学基金项目（7184216）

Research progresses of wound repair by exosomes derived from mesenchymal stem cells

LIU Qingwu ^1,2, CHEN Jia ^1,2, MENG Yujiao ^1,2, FENG Fang ², GUO Xiwei ¹, GUO Jianning ^1,2, ZHANG Jinchao¹, LIN Yan ¹, HE Xiujuan ², LI Ping ^1,2

¹ Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China; ²Beijing University of Chinese Medicine, Beijing 100029, China

Received:2019-03-18 Revised:2019-05-30 Online:2019-07-26 Published:2019-07-29

摘要/Abstract

摘要：

外泌体（exosomes）是细胞分泌的膜性囊泡，其作为干细胞旁分泌因子参与了创面修复。该文对近年间充质干细胞外泌体促进创面修复的研究进展进行综述，外泌体通过调控炎症反应、促进细胞增殖及血管再生、调控细胞外基质重塑及抑制瘢痕形成等多种途径全面地参与了创面修复。工程化干细胞可提高其外泌体功效和产量，为外泌体临床应用带来了巨大的潜力和优势。

关键词: 间充质干细胞, 外泌体, 皮肤, 创面修复, 研究进展

Abstract:

Exosomes are membranous vesicles secreted by cells and promote wound healing by paracrine after secretion from stem cells. This article reviews recent advances of wound repair by exsosomes derived from mesenchymal stem cells. By regulating inflammation, promoting fibroblast proliferation and angiogenesis, regulating extracellular matrix remodeling, and inhibiting scar formation, mesenchymal stem cell exosomes can promote wound repair. Furthermore, engineered stem cells can increase their exosomes efficacy and yield, and provide great advantages to the clinical application of exosomes.

Key words: mesenchymal stem cells, exosome, skin, wound repair, research progress

中图分类号:

R392
R615

刘青武，陈佳，蒙玉娇，冯放，郭昕炜，郭简宁，张金超，林燕，何秀娟，李萍. 间充质干细胞源性外泌体及其在创面修复中的研究进展[J]. 中国临床药理学与治疗学, 2019, 24(7): 826-832.

LIU Qingwu, CHEN Jia, MENG Yujiao, FENG Fang, GUO Xiwei, GUO Jianning, ZHANG Jinchao, LIN Yan, HE Xiujuan, LI Ping. Research progresses of wound repair by exosomes derived from mesenchymal stem cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(7): 826-832.

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间充质干细胞源性外泌体及其在创面修复中的研究进展

Research progresses of wound repair by exosomes derived from mesenchymal stem cells

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