基于熵权的等效数值法在促透剂促透效果综合评价中的运用

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (4): 417-422.

基于熵权的等效数值法在促透剂促透效果综合评价中的运用

李志平¹, 林燕群², 王晖², 梁庆¹

¹广东省皮肤性病防治中心药剂科,广州510500,广东;
² 广东药学院中药药理学教研室,广州510006,广东

收稿日期:2011-03-14 修回日期:2011-03-21 发布日期:2011-06-22
通讯作者: 王晖,男,教授,研究方向:皮肤药理学和数学药理学。Tel: 020-39352057 E-mail: gdwanghui2006@126.com
作者简介:李志平,男,本科,副主任药师,研究方向:医院外用制剂的研究。Tel: 020-87255539 E-mail: lzp882@163.com
基金资助:
广东省科技计划项目(2007A060305006)和广东药学院中青年骨干教师资助项目

Usage of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers

LI Zhi-ping¹, LIN Yan-qiong²,WANG Hui², LIANG Qing¹

¹Pharmacy Department of Guangdong Provincial Center for Skin Disease and STD Control, Guangzhou 510500,Guangdong,China;
²Chinese Medicine Pharmacology Staff Room of Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong, China

Received:2011-03-14 Revised:2011-03-21 Published:2011-06-22

摘要/Abstract

摘要： 目的: 探讨基于熵权的等效数值法在促透剂促透效果综合评价中的运用。 方法: 以扑热息痛为模型药物,利用离体透皮吸收装置,研究氮酮、薄荷醇、樟脑、油酸、丁香油、荆芥油、藿香油促透剂在离体兔背部皮肤上的透皮行为,计算渗透系数、稳态流量、滞后时间、增渗倍数,运用基于熵权的等效数值法对促透效果进行综合评价。 结果: 2％丁香和2％樟脑对扑热息痛的促透效果最好,1％氮酮、2%荆芥油、2％薄荷醇、2％油酸次之,2％广藿香最差。 结论: 基于熵权的等效数值评价法可客观地、公正地评价促透剂的促透效果。

关键词: 熵权, 等效数值法, 促透剂, 促透效果

Abstract: AIM: To investigate the use of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers. METHODS: Using paracetamol as model drug, the promoting effects of azone, menthol, camphor, oleic acid, clove oil, nepeta oil, patchouli oil were detected by transdermal absorption experimentation in rabbit skin in vitro, indexes such as cumulative permeation quantity, penetrating rates, enhancement ratio and lag time were calculated, finally the equivalent numerical method based on entropy weight was used to evaluate the promoting effects of those transdermal enhancers. RESULTS: The promoting effect of 2% camphor and 2% cloves promoted paracetamol was best, 1% Azone, 2% nepeta oil, 2% menthol, 2% oleic acid in sequence,2% patchouli oil was worst. CONCLUSION: The equivalent numerical method based on entropy weight could evaluate the promoting effect of transdermal enhancers objectively and fairly.

Key words: Entropy weight, Equivalent numerical method, Transdermal enhancer, Promoting effect

中图分类号:

李志平, 林燕群, 王晖, 梁庆. 基于熵权的等效数值法在促透剂促透效果综合评价中的运用[J]. 中国临床药理学与治疗学, 2011, 16(4): 417-422.

LI Zhi-ping, LIN Yan-qiong,WANG Hui, LIANG Qing. Usage of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(4): 417-422.

参考文献

[1] 陈艳芬,王同任,王晖,等.主成分分析法对促透剂促透效果的评价[J].中国临床药理学与治疗学2010,15(7):788-793.
[2] 沈非沉,王晖,郭源源,等.几种促透剂联合使用对双氯芬酸钠体外经裸小鼠皮肤吸收的影响[J].数理医药学杂志,2007,20(3):362-363.
[3] 王晖,李昕,许碧莲,等.灰关联聚类法对几种促透剂促透效果的综合评价[J].中国中药杂志,2004,29(5):417-419.
[4] 许碧莲,王晖,许卫铭.新灰色关联分析法对促透剂促透效果的综合评价[J].时珍国医国药,2006,17(6):999-1001.
[5] 秦志斌,边耀璋,李宇峙.等效数值评价法用于交通大气质量评价[J].环境工程,2006,24(2):68,24.
[6] 李凡修,陈武,肖遥.等效数值模型用于污水综合排放级别划分研究[J].环境保护科学,2000,26(5):14-15.
[7] 纪桂霞.大气环境质量的等效数值评价法[J].环境工程,1999,17(6):58-59.
[8] 许卫铭,王宗锐,刘刚,等.一种高效率的药物透皮吸收试验装置的改进[J].中国药理学通报,1997,13(2):185-188.
[9] Jaymin CS, Idris K, Srinivas T, et al. Analysis of percutaneous permeation dataⅡ:Evaluation of the lag time method[J].Int J Pharm,1994,109(3):283-290.
[10] Gao S, Singh J. Mechanism of transdermal transport of 5-fluorouracil by terpenes:carvone,1,8-cineole and thymol[J].Int J Pharm,1997,154(1):67-77.
[11] Williams AC, Barry BW. Terpenes and the lipid-protein-partitioning theory of skin penetration enhancement[J]. P harm Res,1991,8(1):17-20.
[12] 许丽忠,张江山,王菲凤.熵权多目标决策环境监测优化布点模型及应用[J].环境工程,2007,25(1):61-63.
[13] 刘煜,郑恒.基于熵的新产品开发决策方法[J].科技进步与对策,2007,24(2):155-157.
[14] 陈守煜.防洪调度多目标决策理论与模型[J].中国工程科学,2000,2(2):47-52.
[15] 邹进,张勇传.一种多目标决策问题的模糊解法及在洪水调度中的应用[J].水利学报,2003,(1):119-122.
[16] 霍映宝,韩之俊.基于熵原理的上市公司综合评估研究[J].运筹与管理,2004,13(2):118-121.
[17] 楼成君,陈有才,吕有名.熵权多目标决策法在水资源系统决策分析中的应用[J].浙江水利科技,2005,(1):20-22.
[18] 朱福元.熵与信息论[J].自然杂志,1992,15(3):187-188.