常用免疫抑制剂人血中定量监测方法研究进展

摘要/Abstract

摘要： 免疫抑制剂在临床上主要用于治疗自身免疫性疾病和预防脏器移植排斥。免疫抑制剂的使用需要进行治疗药物监测,其检测结果通常作为临床医生调整用药剂量的重要依据之一。本文就目前临床常用的免疫抑制剂他克莫司、环孢素、霉酚酸酯、糖皮质激素及新型免疫抑制剂西罗莫司和依维莫司在人血中浓度的检测方法作一综述,以供参考。

关键词: 免疫抑制剂, 血药浓度监测, 器官移植

Abstract: Immunodepressants are mainly applied to treat autoimmune diseases clinically and organ transplantation.Therapeutic drug monitoring is needed to use immunodepressants and clinicians usually adjust the dosage according to the detection results.This review summarizes the detection methods of immunodepressants in human blood, such as tacrolimus, ciclosporin, mycophenolate , glucocorticosteroid, sirolimus and everolimus.

Key words: Immunodepressants, Therapeutic drug monitoring, Organ transplantation

中图分类号:

R979.5

王燕, 卜雯婷, 李鹏飞, 马萍, 高文静, 孙健姿. 常用免疫抑制剂人血中定量监测方法研究进展[J]. 中国临床药理学与治疗学, 2011, 16(7): 830-836.

WANG Yan, BU Wen-ting, LI Peng-fei, MA Ping, GAO Wen-jing, SUN Jian-zi. Advancement of the drug monitoring methods of immunodepressants in human blood[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(7): 830-836.

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