银屑病局部治疗和遗传药理学的关系

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (10): 1179-1184.

银屑病局部治疗和遗传药理学的关系

孟祥光¹, 李智¹, 王先猛², 周宏灏¹

¹中南大学临床药理研究所,长沙 4100781,湖南;
²郑州市中心医院,郑州450007,河南

收稿日期:2012-07-24 修回日期:2012-09-13 发布日期:2012-10-19
通讯作者: 周宏灏,通信作者,男,院士,博士生导师,研究方向:遗传药理学和临床药理学。Tel: 0731-84805380 E-mail: Hhzhou2003@163.com
作者简介:孟祥光,男,在读博士,研究方向:遗传药理学和临床药理学。Tel: 0731-84805380 E-mail: mxgmxgmxgmxgmxg@126.com
基金资助:
国家自然科学基金资助项目(30801421、30901834、81001476、81072706); 长江学者和创新团队发展计划资助项目(IRT0946)

Advances in Pharmacogenetics of Topical Therapies for Psoriasis

MENG Xiang-guang¹, LI Zhi¹, WANG Xian-meng², ZHOU Hong-hao¹

¹Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 410078 Changsha, Hunan,China;
²Department of Pharmacy, Zhengzhou Central Hospital Affiliated to Zhengzhou University, 450007 Zhengzhou , Henan,China

Received:2012-07-24 Revised:2012-09-13 Published:2012-10-19

摘要/Abstract

摘要： 银屑病是一种炎症过度增生性皮肤病,有强烈的遗传易感性,主要受到遗传、免疫和环境的影响。由于大部分患者病情处于轻中度,所以相比全身治疗,局部治疗具有费用低、用药方便且安全性高的特点,因此具有更大的临床意义。然而,目前涉及银屑病局部治疗的遗传药理学研究却很少。本文主要对近几年银屑病局部治疗反应和遗传因素的关系进行一个较为全面的综述,以期为银屑病患者的个体化医学提供理论指导。

关键词: 银屑病, 遗传药理学, 维生素D, 焦油, 地蒽酚, 光疗

Abstract: Psoriasis is an inflammatory hyperproliferative skin disease with a strong genetic susceptibility and influenced by genetic, immunological and environmental factors. Because the topical treatment is characterized of low cost, proper efficiency and high safety , it is commonly selected for most patients with mild to moderate psoriasis. However, the pharmacogenetics studies on the topical treatment are sparse. This review summarizes the correlations between genetic factors and topical agents to provide the theoretical guidance for the personalized medication in psoriasis.

Key words: Psoriasis, Pharmacogenetics, Vitamin D, Coal tar, Dithranol, Photochemotherapy

中图分类号:

R968

孟祥光, 李智, 王先猛, 周宏灏. 银屑病局部治疗和遗传药理学的关系[J]. 中国临床药理学与治疗学, 2012, 17(10): 1179-1184.

MENG Xiang-guang, LI Zhi, WANG Xian-meng, ZHOU Hong-hao. Advances in Pharmacogenetics of Topical Therapies for Psoriasis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(10): 1179-1184.

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