银屑病全身治疗的遗传药理学进展

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (11): 1307-1313.

银屑病全身治疗的遗传药理学进展

孟祥光¹, 倪文琼², 王超³, 马登轩⁴, 李智¹, 周宏灏 ¹

¹中南大学临床药理研究所,长沙 410078,湖南;
²郑州市中心医院,郑州 450007,河南;
³周口市食品药品检验所,周口 466000,河南;
⁴开封朱仙镇卫生院,开封 475131,河南

收稿日期:2012-08-23 修回日期:2012-10-15 发布日期:2012-12-04
通讯作者: 周宏灏,通信作者,男,中国工程院院士,博士生导师,研究方向:遗传药理学和临床药理学。Tel: 0731-84805380 E-mail: Hhzhou2003@163.com
作者简介:孟祥光,男,在读博士,研究方向:遗传药理学和临床药理学。Tel: 0731-84805380 E-mail: mxgmxgmxgmxgmxg@126.com

Advances in pharmacogenetics of systemic therapies for psoriasis

MENG Xiang-guang¹, NI Wen-qiong², WANG Chao³, MA Deng-xuan⁴, LI Zhi¹, ZHOU Hong-hao¹

¹Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, Hunan,China;
²Department of Pharmacy, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan,China;
³Institute for Food and Drug Control, Zhoukou 466000,Henan,China;
⁴Kaifeng Zhuxian Town Health Centers, Kaifeng 475131, Henan,China

Received:2012-08-23 Revised:2012-10-15 Published:2012-12-04

摘要/Abstract

摘要： 银屑病是一种炎症过度增生性皮肤病,有强烈的遗传易感性。主要受到遗传、免疫和环境的影响。由于部分患者病情处于中重度,局部治疗效果不佳,所以必须施以全身治疗。但全身治疗费用高且疗效和毒性个体化差异大,因此,涉及银屑病全身治疗的遗传药理学研究意义重大。本文主要对近几年银屑病全身治疗和遗传的关系进行一个较为全面的综述,以期为银屑病患者的个体化医学提供理论指导。

关键词: 银屑病, 遗传药理学, 甲氨蝶呤, 环孢素A, 阿维A酸

Abstract: Psoriasis is an inflammatory hyperproliferative skin disease with a strong genetic susceptibility and influenced by genetic, immunological and environmental factors. Because most patients with moderate to severe psoriasis cannot benefit from the topical treatment, they have to treat with systemic agents. While the systemic treatment is characterized of high medical cost and large inter-individual variations in efficacy and adverse reaction, the studies on pharmacogenetics of systemic therapies for Psoriasis play an important role in clinic.This review summarizes the correlations between genetic factors and systemic agents to provide the theoretical guidance for the personalized medication in psoriasis.

Key words: Psoriasis, Pharmacogenetics, Methotrexate, Cyclosporine A, Acitretin

中图分类号:

R751.05

孟祥光, 倪文琼, 王超, 马登轩, 李智, 周宏灏. 银屑病全身治疗的遗传药理学进展[J]. 中国临床药理学与治疗学, 2012, 17(11): 1307-1313.

MENG Xiang-guang, NI Wen-qiong, WANG Chao, MA Deng-xuan, LI Zhi, ZHOU Hong-hao. Advances in pharmacogenetics of systemic therapies for psoriasis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(11): 1307-1313.

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