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中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (12): 1338-1342.

• 基础研究 • 上一篇    下一篇

2012年我院临床分离病原菌及耐药性监测分析

杨会志, 荚恒敏, 张莉莉   

  1. 安徽医科大学附属省立医院,合肥 230001,安徽
  • 收稿日期:2012-11-05 修回日期:2012-12-04 发布日期:2012-12-31
  • 作者简介:杨会志,男,硕士研究生,主要研究方向:血液病及感染性疾病。Email:yanghz@sina.com

Distribution and drug resistance of pathogens causing nosocomial infections in 2012

YANG Hui-zhi, JIA Heng-min, ZHANG Li-li   

  1. Affiliated Provincial Hospital of Anhui Medical University,Hefei 230000,Anhui,China
  • Received:2012-11-05 Revised:2012-12-04 Published:2012-12-31

摘要: 目的: 了解医院感染病人病原菌的分布及其耐药情况,指导临床合理使用抗菌药物。方法: 收集2012年1~6月份医院分离出的所有病原菌,采用VITEK-2对其进行鉴定及药物敏感试验,WHONET5.5软件进行数据分析。结果: 共分离出病原菌2791株,以大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌最多见,分别占 18.99%、15.84%、11.03%、8.53%、7.45%;肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌的耐药率较高,其中鲍曼不动杆菌的耐药最严重。结论: 医院感染病原菌的分离率和耐药性逐年增加,为控制多重耐药菌的蔓延,必须加强抗菌药物的合理使用。

关键词: 细菌, 病原菌, 耐药性

Abstract: AIM: To investigate the distribution and drug resistance of pathogens causing nosocomial infections, and consequently guide rational use of antibiotics. METHODS: A retrospective study was performed to investigate the distribution and drug resistance of gram-negative bacterial isolated from our hospital during January 2012 to June 2012, and the WHONET 5.4 software was used to analyze the data based on the guideline of CLSI 2011 version. RESULTS: 2791 bacterial strains were isolated, the most common pathogens identified were Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus lactis, the detection rate were 18.99%,15.84%,11.03%,8.53%,7.45%, respectively; Klebsiella pneumonia, Pseudomonas aeruginosa, Acinetobacter baumannii have higher drug-resistant rate, in which Acinetobacter baumannii is more likely to resistant to antibiotics. CONCLUSION: In order to restrict antibiotic resistance, appropriate use of antibiotics must be strengthened.

Key words: Bacteria Pathogens, Pathogenic bacteria, Antibiotic Resistance

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