关键词: 血必净, 急性呼吸窘迫综合征, 肿瘤坏死因子, 白细胞介素, 抗凝

Abstract: AIM: To observe the effect of Xuebijing injection on cytokine, coagulation function, and pulmonary function in patients with acute respiratory distress syndrome (ARDS).METHODS: From February 2008 to February 2010, a clinical study was conducted on consecutive adult patients with ARDS in department of intensive care medicine. The patients were divided into test group (30 patients) and control group (29 patients). Both groups were treated with the routine therapy of ARDS according to the ALI/ARDS guidelines of Society of Critical Care Medicine 2006, and in addition, Xuebijing injection was used in a dose of 50mL three times a day for 7 days in test group. Acute physiology and chronic health evaluationⅡ(APACHE Ⅱ)score,modified lung injury score(MLIS),partial pressure of oxygen(PaO₂),partial pressure of carbondioxide(PCO₂) and oxygenenation index(PaO₂/FiO₂) were recorded, and contents of interleukin (TNF-α,IL-6,IL-8)and prothrombin time(PT), activated partial thromboplastin time(APTT), platelet count (PLT), fibrinogen(FIB), C-reactive protein(CRP) were measured on before and the 1st,4th,7th days after therapy both two groups.RESULTS: A significant improvement of TNF-α,IL-6,IL-8,PT,APTT,PCO₂,CRP,FIB,PLT was observed, compared with that in the control group on 4th,7th days after treatment(P<0.05).The levels of PaO₂ and PaO₂/FiO₂ were higher in the test group than that in the control group on the 7th day after treatment(P<0.05). While the APACHEⅡscore and MLIS score between two groups had no significant difference.CONCLUSION: Xuebijing injection can play an adjuvant therapy role on ARDS by improve coagulation function, pulmonary function and decreasing the contents of TNF-α,IL-6,IL-8 in serum.

Key words: Xuebijing injection, Acute respiratory distress syndrome, Tumor necrosis factor, Interleukin, Anti-coagulation