ERK信号转导通路在心肌缺血再灌注损伤中的作用

摘要/Abstract

摘要： 细胞外信号调节激酶(ERK1/2)作为丝裂原活化蛋白激酶家族中一个重要的亚族,在调节细胞的生长、分化、应激以及死亡中起重要作用。大量研究表明,ERK信号通路在体内外心肌缺血/再灌注损伤过程中被激活并发挥了重要作用。激活ERK既可以促进细胞存活,也可以介导细胞损伤,这与细胞种类的不同或缺血/再灌注的程度及时程的不同有关。本文就ERK信号转导通路在心肌缺血再灌注损伤中的作用及其机制作一综述。

关键词: 细胞外信号调节激酶, 缺血再灌注损伤, 心肌

Abstract: It has been suggested that extracellular-signal regulated kinsae (ERK), an important subfamily of mitogen-activated protein kinases (MAPKs), plays a pivotal role in modulating cell growth, differentiation, stress and death. Multiple studies showed that: during myocardial ischemia/reperfusion (I/R) injury ex vivo and in vivo, ERK becomes activated and plays a key role in inducing cell survival or cell damage, which might be dependent on the type of cell and the degree and duration of I/R. In this review we focus on the role of ERK pathway in myocardial I/R injury.

Key words: Extracellular-signal regulated kinsae, Ischemia/reperfusion injury, Cardiomyocytes

中图分类号:

R542.2

陈高勇, 张艳美, 石刚刚. ERK信号转导通路在心肌缺血再灌注损伤中的作用[J]. 中国临床药理学与治疗学, 2012, 17(2): 234-240.

CHEN Gao-yong, ZHANG Yan-mei, SHI Gang-gang. Effects of extracellular-signal regulated kinsae signaling pathway on myocardial ischemia/reperfusion injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(2): 234-240.

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