关键词: 疏肝降脂汤, 非酒精性脂肪性肝炎, 中医药疗法

Abstract: AIM: To investigate the therapeutic effects of the liver soothing and lipid reducing decoction on nonalcoholic steatohepatitis (NASH). METHODS: Eighty NASH patients were assigned to two groups randomly and forty in the treatment group accepted the liver soothing and lipid reducing decoction while forty in the control group were treated with Essentiale. Both of the two groups' course of treatment were three months.The therapeutic effects were observed and the test index of liver function, blood lipids and liver B ultrasound of the two groups were examined before and after the treatment.The adverse drug reaction of all patients were observed and recorded for drug safety evaluation. RESULTS: The total effective rate were 87.5% in the treatment group and 65% in the control group (P<0.05). The levels of ALT, AST and γ-GT were decreased significantly after the treatment in both groups (P<0.05) and compared with the control group,there were significant difference (P<0.05). The levels of TC, TG were decreased significantly after the treatment in both groups (P<0.05) but no statistically significant difference were found between the two groups(P>0.05).The liver B ultrasound disease classification was improved significantly in both groups (P<0.05), and more significantly in the treatment group (P<0.05). No adverse reactions were observed in both groups. CONCLUSION: The liver soothing and lipid reducing decoction can improve the liver function and reduce the blood lipids, and ameliorate the clinical symptoms of NASH.

Key words: Liver soothing and lipid reducing decoction, Nonalcoholic steatohepatitis (NASH), Traditional Chinese medicinal therapy