人类白细胞抗原基因多态性与药物不良反应研究进展

摘要/Abstract

摘要： 药物不良反应已成为危害人类健康的重要公共卫生问题。人类白细胞抗原基因(HLA)是目前已知的人类最复杂基因系统。近年来研究发现,人类白细胞抗原基因多态性与药物不良反应之间有着很强的遗传相关性,且部分研究成果在临床已得到很好地应用。本文就人类白细胞抗原基因多态性与药物不良反应之间的研究及其临床应用进行阐述。

关键词: 人类白细胞抗原基因(HLA), 药物不良反应, 药物基因组学

Abstract: Drug adverse reactions which are harmful to human health have become an important public health problem. Human leucocyte antigene is the most complex gene system. Recent years, research has demonstrated that there is a strong genetic link between HLA gene and drug adverse reactions. What's more, some research achievements have also been applied broadly in clinical practice. This review covers the progress between HLA polymorphisms and drug adverse reactions and on its clinical practice

Key words: Human leucocyte antigen(HLA), Drug adverse reactions, Pharmacogenomics

中图分类号:

R968

罗建权, 张伟. 人类白细胞抗原基因多态性与药物不良反应研究进展[J]. 中国临床药理学与治疗学, 2012, 17(7): 828-834.

LUO Jian-quan, ZHANG Wei. Research progress on human leucocyte antigen gene polymorphisms and drug adverse reactions[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(7): 828-834.

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