不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (9): 1033-1037.

不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响

李银, 黎敬锋, 李世光, 王厚阳, 王超, 陈良余, 陆明奎, 蔡大炜

安徽省滁州市第二人民医院心内科,滁州 239000,安徽

收稿日期:2011-11-23 修回日期:2012-05-08 发布日期:2012-09-25
通讯作者: 黎敬锋,通信作者,男,副主任医师,研究方向:心血管病介入治疗。E-mail: lijingfeng6016@126.com
作者简介:李银,男,在职研究生,研究方向:心血管病介入治疗。

Effect of different doses of atorvastatin on cardiovascular complications in patients with type 2 diabetes

LI Yin, LI Jing-feng, LI Shi-guang, WANG Hou-yang, WANG Cao, CHEN Liang-yu, LU Ming-kui, CAI Da-wei

Department of Cardiology,the Second People's Hospital of Chuzhou City,Chuzhou 239000,Anhui,China

Received:2011-11-23 Revised:2012-05-08 Published:2012-09-25

摘要/Abstract

摘要： 目的观察不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响。方法将150例2型糖尿病患者随机分为3组,对照组50例、常规降脂组50例(阿托伐他汀 20 mg/d)、强化降脂组50例(阿托伐他汀 40 mg/d)。各组常规治疗包括抗血小板治疗和降糖(药物和/或胰岛素)治疗。均随访3年,观察各治疗组心血管并发症的发生情况,评价治疗效果。结果与对照组相比,常规降脂组和强化降脂治疗后组TC、低密度脂蛋白-胆固醇(LDL-C)显著下降(P<0.01),高密度脂蛋白-胆固醇(HDL-C)显著升高(P<0.01)。常规降脂组与强化降脂组治疗后比较,TC、LDL-C下降程度和HDL-C升高程度比较差异有统计学意义(P<0.01)。3年内主要心血管并发症与对照组相比,强化降脂组与常规降脂组比例明显降低(P<0.05),且强化降脂组较常规降脂组心血管并发症发生比例明显降低(P<0.05)。结论阿托伐他汀能显著减少2型糖尿病患者心血管并发症的发生,且强化降脂治疗效果更佳,无明显不良反应。

关键词: 阿托伐他汀, 2型糖尿病, 心血管并发症, 影响

Abstract: AIM: To investigate the effect of different doses of atorvastatin on cardiovascular complications in patients with type 2 diabetes. METHODS: 150 cases of type 2 diabetes patients were randomly divided into three groups, control group,conventional lipid-lowering group (atorvastatin 20 mg/d), intensive lipid-lowering group 50 cases (atorvastatin 40 mg/d)(n=50).The conventional therapies in three groups including antiplatelet therapy and hypoglycemic therapy (drugs and/or insulin).All groups were followed up for 3 years, investigate the effect between three groups in cardiovascular complications. RESULTS: Compared with control group,after treatment,the levels of TC and LDL-C were decreased and the levels of HDL-C were increased in conventional lipid-lowering group and intensive lipid-lowering group(P<0.01). After treatment,the TC,LDL-C decreased level and the HDL-C elevated level between conventional lipid-lowering group and intensive lipid-lowering group showed significantly difference(P<0.01). Compared with the control group,the proportion of major cardiovascular complications in 3 years was decreased significantly in the intensive lipid-lowering group and conventional lipid-lowering group(P<0.05). Compared with the conventional lipid-lowering group,the proportion of cardiovascular complications in the intensive lipid-lowering group was decreased significantly (P<0.05).CONCLUSION: Atorvastatin can decrease the cardiovascular complications in patients with type 2 diabetes,the effect of intensive lipid-lowering is better,and has no adverse reaction.

Key words: Atorvastatin, Type 2 diabetes mellitus, Cardiovascular complication

中图分类号:

R587.1

李银, 黎敬锋, 李世光, 王厚阳, 王超, 陈良余, 陆明奎, 蔡大炜. 不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响[J]. 中国临床药理学与治疗学, 2012, 17(9): 1033-1037.

LI Yin, LI Jing-feng, LI Shi-guang, WANG Hou-yang, WANG Cao, CHEN Liang-yu, LU Ming-kui, CAI Da-wei. Effect of different doses of atorvastatin on cardiovascular complications in patients with type 2 diabetes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(9): 1033-1037.

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