关键词: 结核, 治疗, 脂肪肝, 药物性肝损害

Abstract: AIM: To understand the Occurrence mechanism of the anti-tuberculosis drug-induced fatty liver and drug-induced liver injury (DILI). METHODS: 200 tuberculosis(TB)patients were received,liver function and serum lipid were monitored before and after anti-TB treatment,underwent X-ray computer tomography scan fatty liver before and complete treatment. The experimental data were treated statistically.RESULTS: :The incidence of fatty liver was 28.00% (56/200) and the incidence of DILI was 32.00% (64/200) after treatment. The serum ALT, AST levels after treatment were higher than those before treatment ( P<0.05). The ALT levels after treatment in first, second, third months,AST levels after treatment in first, second, third ,fourth months was the most statistically significant difference than before treatment (P<0.01). TG, HDL-C, LDL-C, apoB levels were significantly higher than that before treatment (P<0.05). The TG levels after treatment in second,third,fourth months, LDL-C levels after treatment in third, fouth months, apoB in first, second, third,fourth,fifth months was the most significant than before treatment (P<0.01). The increase　of ALT, AST levels in the serum were significantly postive correlation with the levels of TG, apoB, HDL-C, LDL-C (P<0.05,P<0.01).CONCLUSION: The formation of fatty liver suggests DILI has undergone in anti-tuberculosis treatment. To strengthen the monitoring of blood lipid indexes can, reduce the occurrence of DILI, prevent the formation of fatty liver, ensure the implementation scheme in treatment of tuberculosis.

Key words: Tuberculosis, Treatment, Fatty liver, Drug-induced liver injury