六味地黄丸对2型糖尿病患者血管内皮功能的影响

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (12): 1392-1395.

六味地黄丸对2型糖尿病患者血管内皮功能的影响

楼娟亚, 董凤芹, 张哲, 周伟斌, 陈敏, 叶丹

浙江大学医学院附属第一医院内分泌科,杭州 310003,浙江

收稿日期:2013-01-04 修回日期:2013-11-11 出版日期:2013-12-26 发布日期:2014-01-04
通讯作者: 叶丹,女,硕士,主治医师,研究方向:糖尿病肾病的发病机制。Tel: 0571-87236565 E-mail: yedan7878@126.com
作者简介:楼娟亚,女,本科,主管护师,研究方向:糖尿病患者教育。Tel: 0571-87236866 E-mail: loujuanya@126.com
基金资助:
浙江省中医药科学研究基金计划(2010ZB070)

Effects of Liu wei di huang pills on the vascular endothelial function in type 2 diabetes mellitus

LOU Juan-ya, DONG Fen-qin, ZHANG Zhe, ZHOU Wei-bin, CHEN Min, YE Dan

Department of Endocrinology and Metabolism, the First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, Zhejiang, China

Received:2013-01-04 Revised:2013-11-11 Online:2013-12-26 Published:2014-01-04

摘要/Abstract

摘要： 目的: 探讨六味地黄丸对2型糖尿病患者血管内皮功能的影响。方法: 选择10例正常健康体检者和60例2型糖尿病患者,糖尿病者随机分为2组,对照组给予常规治疗,治疗组在常规西药治疗基础上加用六味地黄丸,疗程为12周,分别测定治疗前后血清一氧化氮(NO)和内皮收缩因子内皮素(ET-1)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)水平,同时行肱动脉介导内皮依赖性舒张功能的超声检测(FMD)。结果: 对照组与治疗组较正常体检组血清NO、SOD、GSH-Px以及FMD水平降低,血清ET-1水平升高(P<0.01),两组较治疗前比较,治疗后血清NO、ET-1、SOD、GSH-Px水平较治疗前改善(P<0.05),FMD值增高,此外,六味地黄丸组较对照组治疗后改善更明显,除FMD外差异有统计学意义(P<0.05)。结论: 在西药基础治疗上,六味地黄丸治疗能改善2型糖尿病患者血管内皮功能。

关键词: 六味地黄丸, 2型糖尿病, 内皮功能

Abstract: AIM: To study the effects of Liu wei di huang pills (LWDH) on the vascular endothelial function in patients with type 2 diabetes mellitus (T2DM).METHODS: Sixty patients with T2DM were randomized into LWDH group (n=30) and routine treatment group (n=30). Meanwhile, 10 healthy subjects served as the normal control group. On the basis of routine western medicine, patients in LWDH group were treated with LWDH, with a treatment course of 12 weeks. The levels of nitric oxide (NO), endothelin-1 (ET-1), super-oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were detected and the level of flow mediated vasodilatation (FMD) was assessed by Doppler ultrasound before and after 12 week treatment in all subjects.RESULTS: Before treatment the level of the ET-1 in LWDH group and routine treatment group was significantly higher than those of control group (P<0.01). However, the levels of the NO, SOD, GSH-PX, and FMD were significantly lower than that in control group (P<0.01). As compared with those before treatment, those indexes after treatment were obviously improved in LWDH group and routine treatment group (P<0.05). Furthermore, the improvement effect in LWDH group was more obvious than that in routine treatment group (P<0.05).CONCLUSION: LWDH pills can ameliorate the vascular endothelial function inT2DM on the basis of routine treatment.

Key words: Liuwei dihuang pills, Type 2 diabetes mellitus, Endothelial function

中图分类号:

R969
R587.1

楼娟亚, 董凤芹, 张哲, 周伟斌, 陈敏, 叶丹. 六味地黄丸对2型糖尿病患者血管内皮功能的影响[J]. 中国临床药理学与治疗学, 2013, 18(12): 1392-1395.

LOU Juan-ya, DONG Fen-qin, ZHANG Zhe, ZHOU Wei-bin, CHEN Min, YE Dan. Effects of Liu wei di huang pills on the vascular endothelial function in type 2 diabetes mellitus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1392-1395.

参考文献

[1] 孙丰雷. 高血糖对血管内皮功能的研究进展[J]. 中西医结合心脑血管杂志, 2009, 7(6): 724 -725.
[2] Penna C, Rastaldo A, Mancardi D, et al. Effect of endothelins on the cardiovascular system[J]. J Cardiovasc Med, 2006, 7(9): 645-652.
[3] 陈艾东, 李娟, 谢海棠. 内皮素心血管效应的研究进展[J]. 中国临床药理学与治疗学, 2011, 16(8): 937-944.
[4] Kyra EP, Tschakovsky ME. The relationship between shear stress and flow-mediated dilatation implications for the assessment of endothelial function[J]. J Physiol, 2005, 568(2): 357-369.
[5] Wang XX, Sun ZL, Yu JY. Effect of Liuwei Dihuang soft capsule and Ginkgo leaf tablet on serum regulated upon activation, normal T cell expressed and secreted in patients with diabetes mellitus type 2[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2007, 27(4): 315-317.
[6] 薛耀明, 朱波, 罗仁. 六味地黄丸在糖尿病治疗中的应用与研究[J]. 现代中西医结合杂志, 2005, 14(14): 925-927.
[7] Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force[J]. AM Coll Cardiol, 2002, 39(2): 257-265.
[8] Deng S, Deng PY, Jiang JL. Aspirin protected against endothelial damage induced by LDL: role of endogenous NO synthase inhibitors in rats [J]. Acta pharmacol Sin, 2004, 25(12): 1633-1639.
[9] Baynes JW. Role of oxidative stress in development of complication in diabetes [J]. Diabetes, 1991, 11(40): 405.
[10] 张军, 张爱芳, 李秀才. 六味地黄丸的临床应用新进展[J]. 中华实用中西医志, 2008, 21(23): 1756- 1758.
[11] 王敏. 六味地黄丸合用消渴丸对糖尿病大鼠血糖及血脂代谢的实验研究[J]. 中华实用中西医杂志, 2003, 3(16): 810.

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