调节Sirt1的microRNA的研究进展

摘要/Abstract

摘要： 沉默信息调节因子1(Silent information regulator 1, Sirt1)是沉默信息调节因子(Silent information regulator,sir2)家族中的一员,是NAD⁺依赖的Ⅲ类组蛋白去乙酰化酶。Sirt1在细胞的生存、凋亡、肿瘤的发生发展、代谢性疾病以及抗衰老等方面扮演着非常重要的角色。microRNA(miRNA)是一组广泛存在于真核生物中的、短小的、不编码蛋白质的单链RNA。近年来研究表明,miRNA能从转录后水平调控Sirt1的表达。因此,调控Sirt1的miRNA可能成为治疗许多疾病的新靶点而倍受研究者们广泛关注。

关键词: Sirt1, miRNA

Abstract: Sirt1 is a member of silent information regulator (Sir2) family, which is a class III histone NAD+ - dependent deacetylase playing a pivotal role in the cell survival,apoptosis, tumor development, metabolic diseases and anti-aging.MicroRNA (miRNA) is a short,no encoding,single-stranded RNA that exists in eukaryotic organisms. Recent studies show that miRNA can regulate the expression of Sirt1 at the post-transcriptional level. Therefore, miRNA may become a new target in the treatment of many diseases, which has been the focus of researchers.

Key words: Sirt1, miRNA

中图分类号:

R965.2

万静枝, 袁丁, 王婷. 调节Sirt1的microRNA的研究进展[J]. 中国临床药理学与治疗学, 2013, 18(12): 1430-1435.

WAN Jing-zhi, YUAN Ding, WANG Ting. Research advances in Sirt1 regulating microRNA[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1430-1435.

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