丹参注射液对孕晚期S/D异常孕妇人绒毛膜促性腺激素水平影响及临床意义

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (4): 429-432.

丹参注射液对孕晚期S/D异常孕妇人绒毛膜促性腺激素水平影响及临床意义

盛少琴, 裘雅芬, 潘茜茜, 何吉庆

杭州师范大学附属医院妇产科,杭州 310015,浙江

收稿日期:2012-01-09 出版日期:2013-04-26 发布日期:2013-04-26
作者简介:盛少琴,女,硕士,副主任医师,研究方向:围产医学。Tel: 13065715908 E-mail: shshaoqin@sina.com

Effect and clinical significance of Danshen injection on human chorionic gonadotropin of abnormal systolic/diastolic ratio in the third trimester

SHENG Shao-qin, QIU Ya-fen, PAN Qian-qian, HE Ji-qing

Department of Obstetrics and Gynecology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China

Received:2012-01-09 Online:2013-04-26 Published:2013-04-26

摘要/Abstract

摘要： 目的: 观察丹参注射液对孕晚期脐动脉S/D异常孕妇人绒毛膜促性腺激素水平的影响。方法: 选择孕晚期脐动脉血流S/D异常的孕妇100例,随机分为对照组和观察组各50例,前者予5％葡萄糖 500 mL+维生素C 2.0 g 静滴,后者再加用5％葡萄糖 500 mL+丹参注射液 10 mL,7 d 1疗程。治疗前后分别检测两组脐动脉血流PI、RI、S/D值及血清β-hCG水平。结果: 治疗后两组孕妇脐动脉血流PI、RI、S/D值及血清β-hCG水平均较治疗前下降,分别比较,差异均有统计学意义(P<0.01)。治疗后观察组血清β-hCG水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。血清β-hCG及脐动脉血流S/D值之间呈正相关关系(r=0.485,0.458,P<0.01)。结论: 丹参注射液用于孕晚期S/D异常疗效好,结合血清β-hCG测定可以提高对妊娠晚期胎盘功能异常的检出率。

关键词: 丹参注射液, 人绒毛膜促性腺激素, 孕晚期, S/D异常

Abstract: AIM: To observe the effect and clinical significance of Danshen injection on human chorionic gonadotropin of abnormal systolic/diastolic ratio in the third trimester.METHODS: 100 third trimester women with abnormal systolic/diastolic ratio were randomly divided into the control group (n=50) and treatment group (n=50). Control group was given 5% glucose 500 mL+vitamin C 2.0 g. Treatment group was given the same medication as the control group and 5% glucose 500 m+Danshen injection 10 mL, seven days one period of treatment. Umbilical artery PI,RI,S/D and concentration of β-hCG in maternal serum were detected before and after the medication.RESULTS: PI,RI,S/D and β-hCG level in the treatment group were higher than that of the control group(P<0.05); PI,RI,S/D and β-hCG level of the two groups before treatment were higher than that of the two groups after treatment (P<0.01); β-hCG level was positively correlated with S/D(r=0.485,0.458,P<0.01).CONCLUSION: Danshen injection treatment abnormal systolic/diastolic ratio in the third trimester for its excellent curative effect, with serum β-hCG level measurement can increase the detection rate of abnormal placental function.

Key words: Danshen injection, Human chorionic gonadotropin, Third trimester, Abnormal systolic/diastolic ratio

中图分类号:

盛少琴, 裘雅芬, 潘茜茜, 何吉庆. 丹参注射液对孕晚期S/D异常孕妇人绒毛膜促性腺激素水平影响及临床意义[J]. 中国临床药理学与治疗学, 2013, 18(4): 429-432.

SHENG Shao-qin, QIU Ya-fen, PAN Qian-qian, HE Ji-qing. Effect and clinical significance of Danshen injection on human chorionic gonadotropin of abnormal systolic/diastolic ratio in the third trimester[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 429-432.

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