核转录因子E47的功能研究进展

摘要/Abstract

摘要： E47是一个碱性螺旋环螺旋(Basic Helix-Loop-Helix,bHLH)蛋白,作为真核生物的一个重要转录因子,它参与了细胞周期调控,促进细胞衰老;调控胰岛素和胰高血糖素基因的转录;调节免疫细胞增生及免疫因子的合成;对骨骼肌和平滑肌的生成,以及神经系统的生成也有着重要的作用;还可诱导上皮细胞间质转型过程(EMT)致肿瘤性变化。本文就其主要功能做一综述。

关键词: E47, 生长发育调控, 血糖调节, EMT

Abstract: E47, a member of the Helix-Loop-Helix transcription factor family, has been showed to be important in eukaryotes. It was involved in regulating cell cycle, promoting cell senescent. E47 could regulate Insulin and Glucagon gene transcription, immune cells proliferation and the synthesis of immune factors. In addition, it not only contributed to skeletal and smooth myogenesis, neurogenesis, but also triggered epithelial mesenchymal transition ( EMT ) to tumorigenicity. The main functions of E47 were summarized in this article.

Key words: E47, Growth regulation, Blood glucose regulation, EMT

中图分类号:

姚桂连, 高分飞, 石刚刚. 核转录因子E47的功能研究进展[J]. 中国临床药理学与治疗学, 2013, 18(4): 437-442.

YAO Gui-lian, GAO Fen-fei, SHI Gang-gang. Research development in the functions of the nuclear transcription factor E47[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 437-442.

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