缺血性中风抗氧化治疗的临床问题及研究进展

摘要/Abstract

摘要： 抗氧化剂可以显著降低氧化应激损伤,对缺血性中风具有神经保护作用。然而,抗氧化剂的有效性及副作用问题极大地限制了其临床发展。研究表明,反应氧族(ROS)不仅是缺血性脑损伤的核心因素,而且参与了病后恢复期的组织修复,抗氧化剂的使用障碍可能与ROS复杂的生理作用有关。本文以优化抗氧化剂的使用为目的,阐述缺血性中风后ROS的多重病理生理作用,并对当今抗氧化治疗药物进行综述,通过分析药物运用存在的问题,拟为抗氧化剂基础研究和临床应用提供新的思路。

关键词: 反应氧族, 缺血性中风, 抗氧化剂, P-糖蛋白

Abstract: Antioxidants, which act as neuroprotective agents on ischemic stroke, can significantly reduce injury caused by oxidative stress. However, their low effectiveness and side effects greatly limit the clinical development. Studies have shown that reactive oxygen species (ROS) is not only the core factor in ischemic brain injury, but also involved in the tissue repair in convalescence. Therefore, the obstacles of antioxidant clinical use may be associated with its complex physiological functions. The aim of this article is trying to find how to optimize the usage of antioxidants. Thereby the multiple physiological roles of ROS and the antioxidant therapy after ischemic stroke were reviewed. The usage issues of antioxidants were analyzed as well. It is supposed to provide new perspective reference for basic research and clinical applications of antioxidants.

Key words: Reactive oxygen species, Ischemic stroke, Antioxidants, P-glycoprotein

中图分类号:

岑娟, 张峰, 姬汴生. 缺血性中风抗氧化治疗的临床问题及研究进展[J]. 中国临床药理学与治疗学, 2013, 18(4): 448-454.

CEN Juan, ZHANG Feng, JI Bian-sheng. Clinical issues and research progress of antioxidant therapy on ischemic stroke[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 448-454.

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