抗氧化应激在高血压治疗中的应用

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (5): 580-585.

抗氧化应激在高血压治疗中的应用

刘小丽^1,2, 袁洪^1,2,3, 黄志军^1,3, 李莹^1,3

¹中南大学湘雅三医院临床药理中心;
²中南大学药学院;
³中南大学药物临床评价研究中心,长沙 410013,湖南

收稿日期:2012-08-23 修回日期:2013-04-10 出版日期:2013-05-26 发布日期:2013-05-22
通讯作者: 袁洪,男,教授,博士生导师,研究方向:高血压个体化治疗、心血管临床药理。Tel: 0731-88618319 E-mail: yuanhong01@vip.sina.com
作者简介:刘小丽,女,在读研究生,研究方向:心血管药理。Tel: 15273110046 E-mail: lxl7651518 @163.com
基金资助:
国家“重大新药创制”科技重大专项(2012ZX09303014-001);重大基础研究前期研究专项(2011CB512001)

Application of antioxidant stress in the therapy of hypertension

LIU Xiao-li^1,2, YUAN Hong^1,2,3, HUANG Zhi-jun^1,3, LI Ying^1,3

¹Clinical Pharmacology Center, the Third Xiangya Hospital of Central South University;
²Department of Pharmacy, Central South University;
³Drug Clinical Evaluation Research Center, Central South University, Changsha 410013, Hunan,China

Received:2012-08-23 Revised:2013-04-10 Online:2013-05-26 Published:2013-05-22

摘要/Abstract

摘要： 高血压是最常见的心血管疾病之一。近年来大量研究表明,氧化应激是血管损伤的主要原因,可能是导致高血压的重要病理机制。活性氧簇(Reactive oxygen species, ROS)水平的升高,导致氧化应激水平增加,诱导血压升高。高血压进一步促进ROS生成,导致组织氧化损伤。近年来抗氧化应激在心血管疾病治疗中的应用引起了国内外众多研究者关注,并且抗氧化应激在高血压治疗的临床应用方面取得了一定成效。本文主要就氧化应激导致高血压的机制及抗氧化应激治疗展开综述。

关键词: 氧化应激, 活性氧, 高血压, 治疗

Abstract: Hypertension is one of the most common cardiovascular diseases. In recent years, a large number of studies have shown that oxidative stress is the main reason for the vascular injury, which may be an important pathological mechanism that can lead to hypertension. The increasing level of reactive oxygen species (ROS), leading to increased oxidative stress induced an increase in blood pressure. Hypertension will further promote the generation of ROS, leading to tissue oxidative injury. Recently, the anti-oxidative stress therapy research attracted the attention of many researchers at home and abroad. The clinical application of oxidative stress in the treatment of hypertension have achieved certain results. The aim of the present review is to describe the contribution of oxidative stress to hypertension and anti-oxidative stress pharmacotherapy.

Key words: Oxidative stress , ROS , Hypertension, Therapy

中图分类号:

R544

刘小丽, 袁洪, 黄志军, 李莹. 抗氧化应激在高血压治疗中的应用[J]. 中国临床药理学与治疗学, 2013, 18(5): 580-585.

LIU Xiao-li, YUAN Hong, HUANG Zhi-jun, LI Ying. Application of antioxidant stress in the therapy of hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(5): 580-585.

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